An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles.
An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles.
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DOI：
10.3389/fphar.2018.00169
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发表时间：
2018
影响因子：
5.6
通讯作者：
Ahn BC
中科院分区：
文献类型：
--
作者：
Gangadaran P;Hong CM;Ahn BC
细胞外囊泡（EV）目前被认为是有前途的药物递送载体。EV是天然存在的囊泡，其表现出许多有利于用作药物递送载体的特征。此外，EV具有治疗癌症和其他疾病的固有特性。对于使用EV作为药物递送载体的研究和临床转化，EV的体内跟踪是必不可少的。最新的分子成像技术可以在活体动物中追踪EV。然而，每种分子成像技术都有其特定的优点和局限性，因此，了解分子成像技术对于选择最合适的成像技术以实现所需的成像目标至关重要。在这篇综述中，我们总结了电动汽车的特点，药物输送车辆和分子成像技术用于可视化和监测电动汽车在体内环境。此外，我们提供了一个感性的视觉电动汽车作为药物输送车辆和在体内监测电动汽车使用分子成像技术。
Extracellular vesicles (EVs) are currently being considered as promising drug delivery vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to serve as drug delivery vehicles. In addition, EVs have inherent properties for treatment of cancers and other diseases. For research and clinical translation of use of EVs as drug delivery vehicles, in vivo tracking of EVs is essential. The latest molecular imaging techniques enable the tracking of EVs in living animals. However, each molecular imaging technique has its certain advantages and limitations for the in vivo imaging of EVs; therefore, understanding the molecular imaging techniques is essential to select the most appropriate imaging technology to achieve the desired imaging goal. In this review, we summarize the characteristics of EVs as drug delivery vehicles and the molecular imaging techniques used in visualizing and monitoring EVs in in vivo environments. Furthermore, we provide a perceptual vision of EVs as drug delivery vehicles and in vivo monitoring of EVs using molecular imaging technologies.
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影响因子：
8
作者：
Banizs AB;Huang T;Dryden K;Berr SS;Stone JR;Nakamoto RK;Shi W;He J
通讯作者：
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影响因子：
12.4
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影响因子：
46.9
作者：
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通讯作者：
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影响因子：
8
作者：
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Mariotti R
DOI：
10.1016/j.nano.2017.03.001
发表时间：
2017-07-01
影响因子：
5.4
作者：
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通讯作者：
Gupta, Ramesh C.