Validation of 4D Flow based relative pressure maps in aortic flows
Validation of 4D Flow based relative pressure maps in aortic flows
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DOI：
10.1016/j.media.2021.102195
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发表时间：
2021-08-20
影响因子：
10.9
通讯作者：
Bertoglio, Cristobal
中科院分区：
文献类型：
--
作者：
Nolte, David;Urbina, Jesus;Bertoglio, Cristobal
虽然压差测量的临床金标准是有创导管，但4D Flow MRI是一种很有前途的非侵入性量化工具，它通过不可压缩的Navier-Stokes方程将高度空间分辨的速度测量与压差联系起来。在这项工作中，我们提供了一个验证和比较的幻影和临床患者数据的压差图估计器。我们比较了经典的压力泊松估计器（PPE）和新的Stokes估计器（STE）在各种狭窄程度和流动强度下的导管压力测量结果。具体来说，我们使用了几个具有不同解剖和血流动力学严重程度的真实主动脉幻象的4D Flow数据集和两个主动脉缩窄患者。为了研究压差估计器对这些因素的敏感性，通过降低分辨率的子采样、修改分割和添加合成噪声等方法丰富了仿真数据集。总的来说，与置管数据相比，STE方法产生的结果比PPE方法更准确。随着雷诺数的增加，STE的优势变得更加明显，并且在强对流流态中具有更好的捕捉压力梯度的能力。结果表明，STE方法在管腔分割变化方面具有较好的鲁棒性。然而，通过启发式去除墙壁体素，PPE可以在较低的雷诺数下达到相当的精度。(c) 2021提交人。这是一篇基于CC by许可（http://creativecommons.org/licenses/by/4.0/）的开放获取文章。
While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow MRI is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier-Stokes equations. In this work we provide a validation and comparison with phantom and clinical patient data of pressure difference maps estimators. We compare the classical Pressure Poisson Estimator (PPE) and the new Stokes Estimator (STE) against catheter pressure measurements under a variety of stenosis severities and flow intensities. Specifically, we use several 4D Flow data sets of realistic aortic phantoms with different anatomic and hemodynamic severities and two patients with aortic coarctation. The phantom data sets are enriched by subsampling to lower resolutions, modification of the segmentation and addition of synthetic noise, in order to study the sensitivity of the pressure difference estimators to these factors. Overall, the STE method yields more accurate results than the PPE method compared to catheterization data. The superiority of the STE becomes more evident at increasing Reynolds numbers with a better capacity of capturing pressure gradients in strongly convective flow regimes. The results indicate an improved robustness of the STE method with respect to variation in lumen segmentation. However, with heuristic removal of the wall-voxels, the PPE can reach a comparable accuracy for lower Reynolds' numbers. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )