The Role of PIAS SUMO E3-Ligases in Cancer.
The Role of PIAS SUMO E3-Ligases in Cancer.
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DOI：
10.1158/0008-5472.can-16-2958
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发表时间：
2017-04-01
期刊：
影响因子：
11.2
通讯作者：
Scaglioni PP
中科院分区：
文献类型：
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作者：
Rabellino A;Andreani C;Scaglioni PP
苏莫化修饰其靶蛋白的相互作用体、定位、活性和寿命。这一过程调控着多种细胞机制，包括转录、DNA损伤修复、细胞周期进程和细胞凋亡。因此，SUMO化在维持细胞内稳态方面是至关重要的，它的解除调控会导致导致疾病状态的过多细胞过程的腐败。在参与SUMO化的蛋白质中，激活的STAT蛋白抑制因子(PIAS)E3-连接酶最初被描述为转录共调节因子。最近的研究结果还表明，它们在调节蛋白质稳定性和信号转导途径方面发挥了作用。PIAS蛋白与多达60个细胞伙伴相互作用，影响几个细胞过程，最显著的是免疫调节和DNA修复，但也影响细胞的增殖和生存。在这里，我们总结了目前关于它们在肿瘤发生和癌症相关过程中的作用的知识。
SUMOylation modifies the interactome, localization, activity and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the Protein Inhibitor of Activated STAT (PIAS) E3-ligases were initially described as transcriptional co-regulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.