Anthropometric, biochemical, dietary, morbidity and well-being assessments in women and children in Indonesia, India and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper.
Anthropometric, biochemical, dietary, morbidity and well-being assessments in women and children in Indonesia, India and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper.
复制标题
对印度尼西亚、印度和塞内加尔妇女和儿童的人体测量、生化、饮食、发病率和福祉评估：UKRI GCRF 反对发育迟缓中心协议文件。
DOI：
10.1136/bmjpo-2022-001683
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发表时间：
2024
影响因子：
2.6
通讯作者：
Davies-Kershaw H
中科院分区：
文献类型：
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作者：
Davies-Kershaw H
简介 儿童发育迟缓有一个复杂的病因，尤其是在生命的前 1000 天。仅营养干预措施并未在减少/预防儿童发育迟缓方面产生预期效果，这表明了解影响儿童营养状况的环境、生理和心理因素之间复杂相互作用的重要性。本研究将通过评估以下方面来调查孕产妇和儿童的营养、健康和福祉状况及相关因素：(1)人体测量学，(2)营养和健康状况的生物标志物，(3)膳食摄入量，(4)胎儿生长和发育，(5)婴儿发病率，(6)婴幼儿喂养(IYCF)和(7)围产期母亲压力、抑郁和社会支持。方法 本研究将在印度、印度尼西亚和塞内加尔的前瞻性妊娠队列中进行。孕妇将在怀孕的第二个三个月（印度尼西亚、塞内加尔）和第三个三个月（印度）被招募，母亲和婴儿二人组将被招募，直到婴儿 24 个月大。怀孕期间，将进行人体测量，采集静脉血样本进行营养和健康状况的生化评估，采用4次24小时饮食回忆法（MP24HR）评估饮食摄入量，进行胎儿超声评估胎儿生长情况。出生后，将进行人体测量、收集静脉血样本、进行 MP24HR、评估婴儿发病率和 IYCF 实践，并收集母乳样本进行营养成分分析。将测量围产期母亲的压力、抑郁、社会支持和头发皮质醇水平（压力）。这项研究的结果将被纳入跨学科分析中，以研究影响婴儿生长的因素，并为全球减少儿童发育迟缓的努力提供信息。伦理与传播 伦敦卫生和热带医学学院伦理委员会授予伦理批准（17915/RR/17513）；印度政府卫生和家庭福利部国家营养研究所 (ICMR) (CR/04/I/2021)；印度尼西亚大学和 Cipto Mangunkusumo 医院健康研究伦理委员会 (KET-887/UN2.F1/ETIK/PPM.00.02/2019)；塞内加尔国家伦理研究委员会（协议 SEN19/78）；皇家兽医学院 (URN SR2020-0197) 和国际畜牧研究所机构研究伦理委员会 (ILRI-IREC2020-33)。结果将在同行评审期刊上发表，并向政策制定者和参与社区传播。
Introduction Child stunting has a complex aetiology, especially in the first 1000 days of life. Nutrition interventions alone have not produced expected impacts in reducing/preventing child stunting, indicating the importance of understanding the complex interplay between environmental, physiological and psychological factors influencing child nutritional status. This study will investigate maternal and child nutrition, health and well-being status and associated factors through the assessment of: (1) anthropometry, (2) biomarkers of nutrition and health status, (3) dietary intakes, (4) fetal growth and development, (5) infant morbidity, (6) infant and young child feeding (IYCF) and (7) perinatal maternal stress, depression and social support. Methods This study will be conducted in a prospective pregnancy cohort in India, Indonesia and Senegal. Pregnant women will be recruited in the second (Indonesia, Senegal) and third (India) trimester of pregnancy, and the mother and infant dyads followed until the infant is 24 months of age. During pregnancy, anthropometric measures will be taken, venous blood samples will be collected for biochemical assessment of nutrition and health status, dietary intakes will be assessed using a 4-pass-24-hour dietary recall method (MP24HR), fetal ultrasound for assessment of fetal growth. After birth, anthropometry measurements will be taken, venous blood samples will be collected, MP24HR will be conducted, infant morbidity and IYCF practices will be assessed and a sample of breastmilk will be collected for nutrient composition analyses. Perinatal maternal stress, depression, social support and hair cortisol levels (stress) will be measured. The results from this study will be integrated in an interdisciplinary analysis to examine factors influencing infant growth and inform global efforts in reducing child stunting. Ethics and dissemination Ethical approval was granted by the Ethics Committee of the London School of Hygiene and Tropical Medicine (17915/RR/17513); National Institute of Nutrition (ICMR)-Ministry of Health and Family Welfare, Government of India (CR/04/I/2021); Health Research Ethics Committee, University of Indonesia and Cipto Mangunkusumo Hospital (KET-887/UN2.F1/ETIK/PPM.00.02/2019); and the Comité National d'Ethique pour la Recherche en Santé, Senegal (Protocole SEN19/78); the Royal Veterinary College (URN SR2020-0197) and the International Livestock Research Institute Institutional Research Ethics Committee (ILRI-IREC2020-33). Results will be published in peer-reviewed journals and disseminated to policy-makers and participating communities.