Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture.
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture.
复制标题
肾综合征出血热：发病机制和临床表现
DOI：
10.3389/fcimb.2016.00001
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发表时间：
2016
影响因子：
5.7
通讯作者：
Bai XF
中科院分区：
文献类型：
--
作者：
Jiang H;Du H;Wang LM;Wang PZ;Bai XF
汉滩病毒（HTNV）引起肾综合征出血热（HFRS），是东亚特别是中国的一种地方性人兽共患病。汉滩病毒的贮存宿主是野鼠（Apodemus agraricus）。HFRS的主要表现包括急性肾损伤、血管通透性增加和凝血功能异常。本文从病毒因素、免疫因素、宿主遗传因素等方面对肾综合征出血热的发病机制进行综述。此外，将讨论治疗和预防。
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.