Zoster immune globulin. A further assessment.
Zoster immune globulin. A further assessment.
复制标题
带状疱疹免疫球蛋白。
DOI：
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发表时间：
1970
影响因子：
158.5
通讯作者：
P. Brunell
中科院分区：
文献类型：
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作者：
A. Gershon;S. Steinberg;P. Brunell
本文对21名免疫功能低下的儿童（白血病或其他恶性疾病的治疗中）进行了带状疱疹免疫球蛋白的预防效果评价，这些儿童有水痘的家庭暴露。其中6名儿童血清中有水痘带状疱疹病毒感染细胞膜抗原抗体，但没有出现水痘的迹象。其余15名儿童谁没有检测到水痘带状疱疹抗体感染。水痘是严重的一个，轻度的九个和亚临床的五个孩子。所有15名儿童，水痘带状疱疹抗体持续数月至数年后感染。带状疱疹免疫球蛋白的管理似乎是一种有效的方法来修改免疫功能低下的患者水痘。（《新英格兰医学杂志》290：243-245，1974）
Abstract The prophylactic efficacy of zoster immune globulin was evaluated in 21 immunocompromised children (under therapy for leukemia or other malignant processes) who had household exposures to varicella. In six of the children who had serum antibody to antigen on the membrane of cells infected with Varicella Zoster virus, evidence of varicella did not develop. The remaining 15 children who did not have detectable Varicella Zoster antibody became infected. Varicella was severe in one, mild in nine and subclinical in five children. All 15 children, had persistence of Varicella Zoster antibody for months to years after infection. Administration of zoster immune globulin appeared to be an effective method to modify varicella in immunocompromised patients. (N Engl J Med 290:243–245, 1974)