Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response
Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response
复制标题
DOI：
10.1259/bjr.20130676
复制
发表时间：
2014-03-01
影响因子：
2.6
通讯作者：
McKeown, S. R.
中科院分区：
文献类型：
--
作者：
McKeown, S. R.
肿瘤缺氧越来越被认为是癌症治疗中的一个主要有害因素，因为它损害了治疗并推动了恶性进展。这篇综述试图澄清与这一问题相关的氧气水平。有人认为，常氧(20%氧气)是一个非常差的比较“窒息”，即在正常组织中普遍存在的低得多的氧气水平，平均约为5%的氧气，范围约为3%至7.4%。重要的是，应该认识到，未经治疗的肿瘤的中位数氧合水平要低得多，大约在0.3%到4.2%之间，大多数肿瘤的中位数氧水平为2%。这在一定程度上取决于起源的组织，值得注意的是，许多前列腺癌和胰腺肿瘤严重缺氧。此外，治疗还可能导致肿瘤氧合的进一步变化，这种变化可能在纵向上有所不同，在治疗过程中以不总是可预测的方式增加或减少，这些变化往往没有被发现。没有考虑到组织(约5%)和肿瘤(约1%)中的实际生理含氧量的研究可能无法确定推动肿瘤对治疗和/或恶性进展反应的真实环境。当需要与人类肿瘤进行比较时，这在体外基因研究中可能特别重要。
Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies, as it compromises treatment and drives malignant progression. This review seeks to clarify the oxygen levels that are pertinent to this issue. It is argued that normoxia (20% oxygen) is an extremely poor comparator for "physoxia", i.e. the much lower levels of oxygen universally found in normal tissues, which averages about 5% oxygen, and ranges from about 3% to 7.4%. Importantly, it should be recognized that the median oxygenation in untreated tumours is significantly much lower, falling between approximately 0.3% and 4.2% oxygen, with most tumours exhibiting median oxygen levels, < 2%. This is partially dependent on the tissue of origin, and it is notable that many prostate and pancreatic tumours are profoundly hypoxic. In addition, therapy can induce even further, often unrecognized, changes in tumour oxygenation that may vary longitudinally, increasing or decreasing during treatment in ways that are not always predictable. Studies that fail to take cognizance of the actual physiological levels of oxygen in tissues (approximately 5%) and tumours (approximately 1%) may fail to identify the real circumstances driving tumour response to treatment and/or malignant progression. This can be of particular importance in genetic studies in vitro when comparison to human tumours is required.