Cardiorespiratory Fitness and Metabolic Syndrome in Older Men and Women The Dose Responses to Exercise Training (DR's EXTRA) study
Cardiorespiratory Fitness and Metabolic Syndrome in Older Men and Women The Dose Responses to Exercise Training (DR's EXTRA) study
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DOI：
10.2337/dc10-0124
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发表时间：
2010-07-01
期刊：
影响因子：
16.2
通讯作者：
Rauramaa, Rainer
中科院分区：
文献类型：
--
作者：
Hassinen, Maija;Lakka, Timo A.;Rauramaa, Rainer
目的 - 我们研究了老年人最大摄氧量 (Vo(2max)) 与代谢综合征 (MetS) 发生和缓解的关系，为期 2 年。 研究设计和方法 - 受试者为 1,226 名年龄在 57-78 岁之间的男性和女性群体样本。我们在最大运动测试期间通过呼吸气体分析直接评估 Vo(2max)，并使用二分法和连续变量进行 MetS。结果 - 基线 Vo(2max) 增加 1 个 SD 与发生 MetS 的风险降低 44% (95% CI 24-58) 相关。基线 Vo(2max) 最高三分之一的个体发生 MetS 的可能性比最低三分之一的个体低 68% (37-84)。 Vo(2max) 每增加一个 SD，解决 MetS 的可能性就会增加 1.8 (1.2-2.8) 倍。 Vo(2max) 最高的三分之一的个体解决 MetS 的可能性是最低三分之一的个体的 3.9 (1.5-9.9) 倍。结论 - 较高水平的心肺健康可以预防 MetS，并可能在老年人中解决 MetS。
OBJECTIVE - We studied the association of maximum oxygen uptake (Vo(2max)) with the development and resolution of metabolic syndrome (MetS) for 2 years in older individuals.RESEARCH DESIGN AND METHODS - Subjects were a population sample of 1,226 men and women aged 57-78 years. We assessed Vo(2max) directly by respiratory gas analysis during maximum exercise testing and used dichotomous and continuous variables for MetS.RESULTS - One SD increase in baseline Vo(2max) associated with 44% (95% CI 24-58) decreased risk of developing MetS. Individuals in the highest third of baseline Vo(2max) were 68% (37-84) less likely to develop MetS than those in the lowest third. One SD increase in Vo(2max) increased the likelihood to resolve MetS 1.8 (1.2-2.8) times. Individuals in the highest Vo(2max) third were 3.9 (1.5-9.9) times more likely to resolve MetS than those in the lowest third.CONCLUSIONS - Higher levels of cardiorespiratory fitness protect against MetS and may resolve it in older individuals.