MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone
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MiR-30a 通过靶向骨巨细胞瘤中的 RunX2 抑制骨溶解
DOI：
10.1016/j.bbrc.2014.09.076
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发表时间：
2014-10-10
影响因子：
3.1
通讯作者：
Xiao, Jianru
中科院分区：
文献类型：
--
作者：
Huang, Quan;Jiang, Zhengyu;Xiao, Jianru
RunX 2在骨巨细胞瘤的骨溶解过程中起着重要的调控作用。miR-30 a是一种内含子miRNA，具有抑癌活性，但其在骨巨细胞瘤中的作用尚不清楚。在我们的研究中，我们报道了miR-30 a在GCT中下调，而RunX 2高表达。进一步的研究表明，miR-30 a可以通过与RunX 2的3 '-UTR结合，调控RunX 2的表达，从而影响破骨细胞的分化和骨溶解的形成。因此，这些结果表明miR-30 a可以直接靶向RunX 2并参与GCT中的骨质溶解。(C)2014爱思唯尔公司All rights reserved.
RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-30a was down-regulated in GCT whereas RunX2 was highly expressed. Further research proved that miR-30a can regulate the expression of RunX2 by binding to its 3'-UTR, which influence the osteoclast differentiation and osteolysis formation. Thus, these results suggest that miR-30a could directly target RunX2 and participate in osteolysis in GCT. (C) 2014 Elsevier Inc. All rights reserved.