HFE genotype, particulate air pollution, and heart rate variability -: A gene-environment interaction
HFE genotype, particulate air pollution, and heart rate variability -: A gene-environment interaction
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DOI：
10.1161/circulationaha.106.643197
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发表时间：
2006-12-19
期刊：
影响因子：
37.8
通讯作者：
Schwartz, Joel
中科院分区：
文献类型：
--
作者：
Park, Sung Kyun;O'Neill, Marie S.;Schwartz, Joel
背景——空气颗粒物污染与心血管死亡率和发病率相关。与颗粒结合的过渡金属（例如铁）可能是造成这些缔合的原因。血色素沉着病 (HFE) 基因的蛋白质产物调节肺源中铁和二价阳离子的摄取并降低其毒性。与铁吸收增加相关的两种 HFE 多态性（C282Y 和 H63D）可能会改变富含金属的颗粒对心血管系统的影响。方法和结果 - 我们研究了颗粒物之间的关联
Background - Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system.Methods and Results - We investigated the association between particulate matter