VASCULAR PATTERN OF THE SPONTANEOUS C3H MOUSE MAMMARY-CARCINOMA AND ITS SIGNIFICANCE IN RADIATION RESPONSE AND IN HYPERTHERMIA
VASCULAR PATTERN OF THE SPONTANEOUS C3H MOUSE MAMMARY-CARCINOMA AND ITS SIGNIFICANCE IN RADIATION RESPONSE AND IN HYPERTHERMIA
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DOI：
10.1016/0014-2964(80)90152-8
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发表时间：
1980-01-01
影响因子：
8.4
通讯作者：
FALK, P
中科院分区：
文献类型：
--
作者：
FALK, P
自发性C3H小鼠乳腺癌的血管模式从毛细血管网络发展成缺乏小动脉的传入系统，仅由毛细血管样血管和以大窦为特征的传出系统组成。基质和实质生长之间缺乏相关性导致迂回和不均匀的血液供应，并导致传出系统高度闭塞，从而降低血流速率。薄壁组织由单层或多层细胞形成的小管组成，其间毛细血管不能穿透。氧气和营养物质向多层小管内细胞的扩散路径比向外层细胞或单层小管细胞的扩散路径长得多。因此，在前部分，缺氧和严重缺氧可能占上风。坏死的形态与这一假设相符。放疗和热疗可能对这两种肿瘤成分有不同的作用，热疗对前者更有效，放疗对后者更有效。
The vascular pattern of the spontaneous C3H mouse mammary carcinoma develops from a capillary network into an afferent system lacking arterioles and consisting only of capillary-like vessels and an efferent system characterized by large sinuses. Lack of correlation between the growth of stroma and parenchyma leads to a circuitous and uneven blood supply and to a high degree of occlusion of the efferent system with consequent reduction in the rate of blood flow. The parenchyma consists of tubules formed of single or multiple layers of cells between which capillaries do not penetrate. The diffusion pathway of oxygen and nutrients to the inner cells of the multi-layered tubules is considerably longer than that to their outer cells or to the cells of the single-layered tubules. Consequently it is in the former parts that anoxia and severe hypoxia are likely to prevail. The pattern of necrosis agrees with this supposition. Radiation and hyperthermia probably will act differentially on these 2 tumor components, hyperthermia being more effective on the former, radiation on the latter.