Acute neurovascular unit protection by simvastatin in transient cerebral ischemia
Acute neurovascular unit protection by simvastatin in transient cerebral ischemia
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DOI：
10.1179/174313206x153914
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发表时间：
2006-12-01
影响因子：
1.9
通讯作者：
Fenstermacher, Joseph D.
中科院分区：
文献类型：
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作者：
Nagaraja, Tavarekere N.;Knight, Robert A.;Fenstermacher, Joseph D.
在短暂性局灶性脑缺血大鼠模型上评价了辛伐他汀的急性血管和神经保护作用。雄性Wistar大鼠(n=12)，大脑中动脉(MCA)短暂阻断3h后再灌流3h。大脑中动脉结扎30min后，每只大鼠皮下注射辛伐他汀20或40 mg/kg。再灌流3h后，分别用组织学和[C-14]-α-氨基异丁酸(AIB)定量放射自显影定量测定组织损伤和血脑屏障(BBB)开放程度。与未治疗大鼠相比，辛伐他汀(20 mg/kg)治疗组大鼠AIB渗漏体积、组织苍白和AIB分布空间减少(p<；0.05)。较高的药物剂量(40 mg/kg)未见其他影响。这些数据表明，他汀类药物的急性神经保护作用部分是由于减弱了中风引起的血脑屏障通透性变化。
Acute vascular-and neuroprotective effects of simvastatin were evaluated in a rat model of transient, focal cerebral ischemia. Male, Wistar rats (n = 12) underwent transient middle cerebral artery (MCA) occlusion for 3 hours followed by 3 hours of reperfusion. After 30 minutes of MCA occlusion, four rats each were subcutaneously injected with either 20 or 40 mg/kg of simvastatin. At the end of 3 hours of reperfusion, tissue injury and blood-brain barrier (BBB) opening were quantified by histology and [C-14]-alpha-aminoisobutyric acid (AIB)-based quantitative autoradiography (QAR), respectively. Compared with untreated rats, those treated with simvastatin (20 mg/kg) had reduced volumes of AIB leakage, tissue pallor and distribution space for AIB (p < 0.05). No additional effects were seen with the higher drug dose (40 mg/kg). These data suggest that the acute neuroprotective effects of statins are in part owing to attenuation of stroke-induced changes in BBB permeability.