SELECTIVE SPARING OF A CLASS OF STRIATAL NEURONS IN HUNTINGTONS-DISEASE
SELECTIVE SPARING OF A CLASS OF STRIATAL NEURONS IN HUNTINGTONS-DISEASE
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DOI：
10.1126/science.2931802
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
MARTIN, JB
中科院分区：
文献类型：
--
作者：
FERRANTE, RJ;KOWALL, NW;MARTIN, JB
在亨廷顿氏病的尾状核中保存着一个独特的纹状体突起神经元亚群，其中含有烟酰胺腺嘌呤二核苷酸磷酸二磷酸酶。生化分析证实了这种酶在死后脑组织尾状核和壳核中的活性显著增加。这些神经元的抗性提示亨廷顿病的基因缺陷可能被局部生化环境所改变。这一发现可能有助于深入了解作为该疾病特征的基因程序性细胞死亡的本质。
A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in Huntington''s disease. Biochemical assays confirmed a significant increase in the activity of this enzyme in both the caudate nucleus and putamen in postmortem brain tissue form patients with this disease. The resistance of these neurons suggests that the gene defect in Huntington''s disease may be modifiable by the local biochemical environment. This finding may provide insight into the nature of the genetically programmed cell death that is a characteristic of the disease.