Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.
Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.
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DOI：
10.2147/nss.s330939
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发表时间：
2022
影响因子：
3.4
通讯作者：
Krystal AD
中科院分区：
文献类型：
--
作者：
Lunsford-Avery JR;Edinger JD;Krystal AD
睡眠对认知至关重要，但其潜在机制仍不清楚。虽然睡眠持续时间和连续性是两个公认的贡献者，其他因素包括稳态睡眠驱动过程也可能是认知相关睡眠恢复的基础。本研究探讨了睡眠脑电图因素的相对贡献，以确定最显着的睡眠因素，支持心理功能的成人失眠症和健康对照（HC）。患有失眠症（n = 37）和HC（n = 39）的成年人完成了3个晚上的多导睡眠图和复杂的心理任务（转换注意力任务; SAT）。单变量相关性确定了SAT表现的最重要的预测因素（传统PSG，频谱EEG，初始δ峰值和夜间δ下降），然后将其输入多变量线性回归，检查预测因素在考虑缩短/碎片化睡眠后是否仍然显着，以及各组之间的关系是否不同。除了入睡后清醒程度更高（WASO; r = 0.33）之外，夜间δ下降速度更慢（r = 0.50）和初始δ峰值更低（r =-0.38）是SAT表现较差的最重要预测因素。在控制了人口统计学、总睡眠时间和WASO后，过夜δ下降（F（7，68）= 12.52，p < 0.001）和初始δ峰值（F（7，68）= 7.85，p = 0.007）仍然是显著的预测因子。不同受试者组之间的关系相似。研究结果表明，除了睡眠持续时间和连续性之外，与稳态睡眠驱动力的恢复和消散相关的过程可能支持精神运动表现，并广泛支持有和没有失眠的个体的日间功能。未来的研究可能会检查夜间delta动态作为跨诊断过程，支持一系列临床人群的认知相关睡眠恢复。
Sleep is vital to cognition, yet underlying mechanisms remain unclear. Although sleep duration and continuity are two well-established contributors, additional factors—including homeostatic sleep drive processes—may also underlie cognition-related sleep restoration. This study investigates the relative contributions of sleep EEG factors to psychomotor functioning in adults with insomnia and healthy controls (HC) to identify the most significant sleep factors supporting psychomotor functioning. Adults with insomnia (n = 37) and HC (n = 39) completed 3 nights of polysomnography and a complex psychomotor task (switching attention task; SAT). Univariate correlations identified the most significant predictors (traditional PSG, spectral EEG, initial delta peak, and overnight delta decline) of SAT performance, which were then entered into multivariable linear regressions examining whether predictors remained significant after accounting for shortened/fragmented sleep and whether relationships differed across groups. In addition to greater wake after sleep onset (WASO; r = 0.33), a slower overnight delta decline (r = 0.50) and a lower initial delta peak (r = −0.38) were the most significant predictors of poorer SAT performance. Both overnight delta decline (F(7, 68) = 12.52, p < 0.001) and initial delta peak (F(7, 68) = 7.85, p = 0.007) remained significant predictors after controlling for demographics, total sleep time, and WASO. Relationships were analogous across subject groups. Findings suggest that, in addition to sleep duration and continuity, processes related to recovery from and dissipation of homeostatic sleep drive may support psychomotor performance and broadly support daytime functioning in individuals with and without insomnia. Future research may examine overnight delta dynamics as transdiagnostic processes supporting cognition-related sleep restoration across a range of clinical populations.