Assays for the Spectrum of Circulating Tumor Cells.
Assays for the Spectrum of Circulating Tumor Cells.
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循环肿瘤细胞谱的测定。
DOI：
10.1007/978-1-0716-1979-7_37
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pestell,RichardG
中科院分区：
文献类型：
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作者：
Jiao,Xuanmao;Upadhyaya,Chandan;Zhang,Zhao;Zhao,Jun;Li,Zhiping;Patel,VivekI;Pestell,RichardG
具有干细胞特性的癌细胞被称为“癌症干细胞”（CSC）。 CSC具有独特的代谢特性，本质上具有耐药性，可逃避化疗，受miRNA网络调节，并参与肿瘤复发和转移。在转移扩散过程中，循环肿瘤细胞（CTC）侵入远处器官并定居在支持性微环境中。在此过程中，CTC 内的干细胞样特性有助于 CTC 存活并最终促进继发性肿瘤的生长。我们在此描述了 CTC 分析方法，因为它们存在于具有不同特征的不同功能库中。
Cancer cells sharing stem cell properties are called “cancer stem cells” (CSCs). CSCs have distinct metabolic properties, are intrinsically drug resistant evading chemotherapies, are regulated by miRNA networks and participate in tumor relapse and metastases. During metastatic dissemination, circulating tumor cells (CTCs) invade distant organs and settle in supportive niches. In this process, the stem cell–like properties within CTCs contribute to CTC survival and eventually seed the growth of a secondary tumor. We herein describe methodologies for the analysis of CTCs as they reside in distinct functional pools with distinct characteristics.