Lipid droplets in health and disease
Lipid droplets in health and disease
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DOI：
10.1002/1873-3468.14900
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发表时间：
2024-05
期刊：
影响因子：
3.5
通讯作者：
Maria Bohnert;Bianca Schrul
中科院分区：
文献类型：
--
作者：
Maria Bohnert;Bianca Schrul
Lipid droplets are ubiquitous organelles that can be formed by virtually all eukaryotic cells and fulfill central roles in lipid biology. They have a unique architecture that enables them to store variable amounts of neutral lipids such as triacylglycerol and sterol esters in a central hydrophobic core compartment, which is protected from the aqueous cytosol by an outer phospholipid monolayer. This monolayer houses the lipid droplet surface proteome that comprises a large number of lipid metabolism enzymes, which mediate key steps in the biosynthesis and turnover of membrane and storage lipids [1]. In recent years, lipid droplet dysfunctions have started to be recognized as causes for disease, but the underlying cell biological relationships and molecular mechanisms are still largely enigmatic [2, 3].This special issue of FEBS Letters entitled “Lipid droplets in health and disease” aims at providing a broad view of our current understanding of lipid droplet functions in physiological and pathological states. Sixteen review articles highlight recent key discoveries around the lipid droplet life cycle, important technological advances in the field, and insights into the cell biology underlying inherited and acquired diseases related to altered lipid storage. Lipid droplets are formed at the endoplasmic reticulum (ER), where neutral lipids are synthesized by membrane resident enzymes. These neutral lipids are
