Anatomical substrates for functional columns in macaque monkey primary visual cortex
Anatomical substrates for functional columns in macaque monkey primary visual cortex
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DOI：
10.1093/cercor/13.1.15
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发表时间：
2003-01-01
期刊：
影响因子：
3.7
通讯作者：
Bressloff, PC
中科院分区：
文献类型：
--
作者：
Lund, JS;Angelucci, A;Bressloff, PC
在这篇评论中，我们重新审视猕猴初级视觉皮层的皮质柱的概念，并考虑在何种程度上功能定义的列反映了任何一种解剖实体，细分皮层领土。功能研究表明，与不同的反应特性相关的列在不同的空间尺度上映射在皮层中。我们建议，这些属性首先出现在中间层4C通过丘脑传入输入和本地皮层内电路的组合，然后转移到其他层中的柱状方式，通过层间中继，在那里发生额外的处理。然而，有几个属性并不是严格的柱状，因为它们并不出现在所有的皮质层中。与功能柱相反，基于解剖学的皮质柱在其通过区域内横向连接和区域间反馈/前馈途径进行的相互连接方面定义得最清楚。列边界通过扩展到列边界之外的侧抑制和列内的去抑制之间的相互作用来加强。解剖柱作为一个功能调谐单元和横向偏移区域和反馈路径的信息整理点。丘脑输入提供了高对比度的感受野大小的列的神经元，区域内的横向连接提供其低对比度的总和字段的大小，和反馈通路提供环绕调制的感受野响应。
In this review we re-examine the concept of a cortical column in macaque primary visual cortex, and consider to what extent a functionally defined column reflects any sort of anatomical entity that subdivides cortical territory. Functional studies have shown that columns relating to different response properties are mapped in cortex at different spatial scales. We suggest that these properties first emerge in mid-layer 4C through a combination of thalamic afferent inputs and local intracortical circuitry, and are then transferred to other layers in a columnar fashion, via interlaminar relays, where additional processing occurs. However, several properties are not strictly columnar since they do not appear in all cortical layers. In contrast to the functional column, an anatomically based cortical column is defined most clearly in terms of the reciprocal connections it makes, both via intra-areal lateral connections and inter-areal feedback/feedforward pathways. The column boundaries are reinforced by interplay between lateral inhibition spreading beyond the column boundary and disinhibition within the column. The anatomical column acts as a functionally tuned unit and point of information collation from laterally offset regions and feedback pathways. Thalamic inputs provide the highcontrast receptive field sizes of the column's neurons, intra-areal lateral connections provide their low contrast summation field sizes, and feedback pathways provide surround modulation of receptive fields responses.