MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case control study
MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case control study
复制标题
中国人MFGE8多态性与代谢相关指标显着相关，而非代谢综合征：一项巢式病例对照研究
DOI：
10.1016/j.gene.2018.07.060
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Hu Dongsheng
中科院分区：
文献类型：
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作者：
Liu Leilei;Cheng Cheng;Zhang Dongdong;Zhang Ruiyuan;Liu Yu;Sun Xizhuo;Yin Zhaoxia;Li Honghui;Zhao Yang;Wang Bingyuan;Ren Yongcheng;Liu Xuejiao;Liu Dechen;Liu Feiyan;Chen Xu;Zhou Qionggui;Xiong Yihan;Xu Qihuan;Liu Jiali;Hong Shihao;You Ziyang;Hu Dongsheng
背景乳脂球-表皮生长因子8（MFGE 8）基因单核苷酸多态性（SNPs）与代谢综合征（MetS）及代谢相关指标的相关性研究有限。本研究探讨了在中国adultes.MethodsWe进行了巢式病例对照研究的基础上，中国农村队列研究，包括408人MetS和408对照匹配的基线性别，年龄（± 2岁），婚姻状况，和居住村。采用SNPscan基因分型系统对4个多态性位点进行基因分型。结果MFGE8基因多态性与代谢综合征的发病率、收缩压、甘油三酯、空腹血糖均无显著相关性（P> 0.05）。MFGE8rs4932450在显性模型（β = − 0.0218，P = 0.007）和加性模型（β = − 0.0175，P = 0.012）下与高密度脂蛋白胆固醇（HDL-C）水平呈负相关，在隐性模型（β = 4.8848，P = 0.011）下与舒张压（DBP）呈正相关。结论MFGE8基因多态性与中国成年人MetS无相关性，但与DBP、HDL-C及腰围相关。
BackgroundThe correlation between single nucleotide polymorphisms (SNPs) of milk fat globule-epidermal growth factor 8 (MFGE8) and metabolic syndrome (MetS) and metabolism-related indicators are limited. The present study explored the relation in Chinese adults.MethodsWe conducted a nested case–control study based on the Rural Chinese Cohort Study including 408 people with MetS and 408 controls matched by baseline sex, age (±2 years), marital status, and residence village. Four polymorphisms were selected and genotyped by using the SNPscan Genotyping system. Conditional logistic regression was used to estimate the association ofMFGE8polymorphisms with MetS incidence, and linear regression was used to assess the association with metabolism-related indicators in controls.ResultsWe found no significant association ofMFGE8SNPs with MetS incidence or systolic blood pressure, or triglycerides level, or fasting plasma glucose (P> 0.05). However,MFGE8rs4932450 was negatively associated with high-density lipoprotein cholesterol (HDL-C) level under the dominant model (β= −0.0218,P= 0.007) and the additive model (β= −0.0175,P= 0.012) and positively associated with diastolic blood pressure (DBP) under the recessive model (β= 4.8848,P= 0.011). The rs3784751 SNP was associated with increased waist circumference (WC) in controls (β= 0.0307,P= 0.028).ConclusionsMFGE8polymorphisms were not associated with MetS but were related to DBP, HDL-C level, and WC in Chinese adults.