Histamine-induced coronary spasm in regions of intimal thickening in miniature pigs: roles of serum cholesterol and spontaneous or induced intimal thickening.
Histamine-induced coronary spasm in regions of intimal thickening in miniature pigs: roles of serum cholesterol and spontaneous or induced intimal thickening.
复制标题
小型猪内膜增厚区域组胺诱导的冠状动脉痉挛：血清胆固醇和自发或诱导内膜增厚的作用。
DOI：
10.1161/01.cir.74.4.826
复制
发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
M. Nakamura
中科院分区：
文献类型：
--
作者：
K. Egashira;H. Tomoike;Y. Yamamoto;A. Yamada;Y. Hayashi;M. Nakamura
在哥廷根小型猪中通过血管造影和形态测量检查了组胺诱导的冠状动脉痉挛的发病机制。在 36 头连续的 4 至 5 月龄猪中，有 5 头因冠状动脉内注射组胺而引发冠状动脉痉挛，并且对左冠状动脉进行组织学检查，未发现内皮剥脱（第 1 组）。 36 头猪中的 31 头进行了左冠状动脉主要分支的内皮球囊剥脱术，其中 5 头在手术过程中死亡。其余 26 头猪被随机分配到两组中的一组，一组饲喂补充胆固醇（第 2 组，n = 13），另一组饲喂常规低胆固醇饮食（第 3 组，n = 13）。 3 个月后，第 2 组的血清胆固醇从 57 +/- 6 显着增加至 222 +/- 27 mg/dl（p 小于 0.01），但第 3 组保持不变（48 +/- 5 至 55 +/- 6 mg/dl）。给予 H2 阻滞剂西咪替丁（60 mg/kg iv）后，由 10 微克/kg 注射组胺诱导的冠状动脉直径缩小百分比在非裸露部位，P 值分别为 39 +/- 3% 和 24 +/- 2%（第 2 组和第 3 组之间的 p 小于 0.05），在第 2 组和第 3 组的裸露部位，分别为 78 +/- 3% 和 74 +/- 4%（在非裸露部位和裸露部位之间，p 小于 0.01）。第 1、2 和 3 组猪在服用西咪替丁后，组胺诱导的冠状动脉直径缩小百分比与指数曲线上的内膜厚度程度密切相关（r = .92，p 小于 0.001）。由于所有三组中完整部位的狭窄百分比均为 27% (n = 19)，因此应用几何理论预测组胺引起的痉挛部位的狭窄百分比为 33 +/- 3%。因此，响应组胺而导致的冠状动脉收缩增强和内膜增厚在很大程度上可以通过血管壁对自体激素的获得性高反应性来解释。这种现象与血清胆固醇水平无关，可能与动脉粥样硬化演变的基本病理学有独特的联系。
The pathogenesis of histamine-induced coronary spasm was examined angiographically and morphometrically in Göttingen miniature pigs. In five of 36 consecutive pigs that were 4 to 5 months of age, coronary spasm was provoked by the intracoronary administration of histamine, and the left coronary arteries were examined histologically without endothelial denudation (group 1). Endothelial balloon denudation of the major branch of the left coronary artery was performed in 31 of 36 pigs and five died during the procedure. The remaining 26 pigs were randomly allotted to one of two groups, one fed a cholesterol-supplemented (group 2, n = 13) and one fed a regular low-cholesterol diet (group 3, n = 13). After 3 months, serum cholesterol increased significantly from 57 +/- 6 to 222 +/- 27 mg/dl (p less than .01) in group 2, but remained unchanged (48 +/- 5 to 55 +/- 6 mg/dl) in group 3. Percent narrowing of the coronary diameter induced by 10 micrograms/kg ic histamine after administration of the H2 blocker cimetidine (60 mg/kg iv) was 39 +/- 3% and 24 +/- 2% (p less than .05 between groups 2 and 3) at the nondenuded site and 78 +/- 3% and 74 +/- 4% at the denuded site in groups 2 and 3, respectively (p less than .01 between nondenuded and denuded sites). Histamine-induced percent narrowing of the coronary diameter after cimetidine in group 1, 2, and 3 pigs correlated well with the degree of intimal thickness on an exponential curve (r = .92, p less than .001). Since percent narrowing at the intact site was 27% (n = 19) in all three groups, predicted histamine-induced percent narrowing at the spastic site, applying the geometric theory, was 33 +/- 3%. Accordingly, enhanced constriction of the coronary artery with intimal thickening in response to histamine can largely be explained by the acquired hyperresponsiveness of the vascular wall to autacoids. This phenomena, not related to the level of serum cholesterol, may be uniquely linked to the basic pathology of evolution of atherosclerosis.
DOI：
--
发表时间：
1981
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Reidy,MA;Schwartz,SM
通讯作者：
Schwartz,SM