Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer
Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer
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DOI：
10.1111/j.1349-7006.2008.01077.x
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Mori, Masatomo
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Oriuchi, Noboru;Mori, Masatomo
L-[3-F-18]-α-甲基酪氨酸(F-18-FMT)是一种用于正电子发射断层扫描的氨基酸示踪剂。我们进行了一项临床病理研究，以阐明非小细胞肺癌(NSCLC)患者血管生成与F-18-FMT和2-[F-18]-氟-2-脱氧-D-葡萄糖(F-18-FDG)摄取的相关性。本研究共纳入37例非小细胞肺癌患者，进行了F-18-FMT和F-18-FDG的PET检查。用标准化摄取值评价PET示踪剂的摄取。采用免疫组织化学方法检测肿瘤组织中血管内皮生长因子、CD31、CD34、L氨基酸转运蛋白1的表达及Ki-67标记指数，并与临床病理参数及PET示踪剂摄取情况进行相关性分析。血管内皮细胞生长因子的中位数为45%(范围10-78%)。高表达30例(81%，30/37)。在统计学上，血管内皮细胞生长因子的表达与微血管计数的进行性增加有关。VEGF与LAT1表达(P=0.04)、Ki-67标记指数(P=0.01)呈正相关。然而，它与年龄、性别、疾病分期、肿瘤大小和组织学无相关性。微血管密度(MVD)与各参数均无相关性。F-18-FMT和F-18-FDG摄取与血管内皮生长因子显著相关(P<；0.0001，P=0.026)，而F-18-FMT和血管内皮生长因子的相关性更有意义。本研究表明，用F-18-FMT和F-18-FDG对原发肿瘤的代谢活性进行PET研究，与肿瘤血管生成和非小细胞肺癌的增殖活性有关。(癌症科学2009；100：753-758)
L-[3-F-18]-alpha-methyltyrosine (F-18-FMT) is an amino-acid tracer for positron-emission tomography (PET). We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with F-18-FMT and 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) uptake in patients with non-small cell lung cancer (NSCLC). Thirty-seven NSCLC patients were enrolled in this study, and two PET studies with F-18-FMT and F-18-FDG were performed. Uptake of PET tracers was evaluated with standardized uptake value. Vascular endothelial growth factor (VEGF), CD31, CD34, L-type amino acid transporter 1 (LAT1) and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers. The median VEGF rate was 45% (range, 10-78%). High expression was seen in 30 patients (81%, 30/37). VEGF expression was statistically associated with progressively growing microvessel count. VEGF showed a correlation with LAT1 expression (P = 0.04) and Ki-67 labeling index (P = 0.01). However, it showed no correlation with age, gender, disease stage, tumor size, and histology. Microvessel density (MVD) showed no correlation with any parameters. F-18-FMT and F-18-FDG uptake correlated significantly with VEGF (P < 0.0001, P = 0.026, respectively), whereas the correlation of F-18-FMT and VEGF was more meaningful. The present study demonstrated that the metabolic activity of primary tumors as evaluated by PET study with F-18-FMT and F-18-FDG is related to tumor angiogenesis and the proliferative activity in NSCLC. (Cancer Sci 2009; 100: 753-758)