Anterior Segment Optical Coherence Tomography of Conjunctival Nevus
Anterior Segment Optical Coherence Tomography of Conjunctival Nevus
复制标题
DOI：
10.1016/j.ophtha.2010.09.016
复制
发表时间：
2011-05-01
期刊：
影响因子：
13.7
通讯作者：
Shields, Jerry A.
中科院分区：
文献类型：
--
作者：
Shields, Carol L.;Belinsky, Irina;Shields, Jerry A.
目的：应用前段光学相干断层扫描(AS-OCT)评价结膜痣。设计：回顾性干预病例系列。参与者：AS-OCT检查21例(22眼)结膜痣患者，用于评价和检测结膜痣内的囊性病变。干预：前段OCT。主要观察指标：评价和检测囊性病变。结果：AS-OCT可显示包括深缘在内的所有边缘，前缘高分辨率100%，后缘高分辨率82%，外侧高分辨率86%。所有病例均可见密度较大、形态均匀的色素痣。86%的患者有不同程度的深部光学阴影，主要来自色素痣。裂隙灯生物显微镜检出18例(82%)，AS-OCT检出17例(77%)。与病理结果对照，AS-OCT诊断固有囊性病变的敏感性为80%，特异性为100%，阳性预测值(PPV)为100%，阴性预测值(NPV)为60%。裂隙灯生物显微镜(由有经验的观察者)与组织病理学相比较，发现囊性病变的敏感度为100%，特异度为100%，PPV为100%，NPV为100%。结论：前段OCT提供了结膜痣的高分辨率成像，能够显示所有边缘并提供有关囊肿存在的信息，这在诊断中很重要。主要缺点是色素在雀巢内部对更深层次结构的光学阴影。财务披露(S)：作者(S)对本文讨论的任何材料没有专有或商业利益。眼科2011；美国眼科学会118：915-919(C)2011。
Purpose: To evaluate conjunctival nevi using anterior segment optical coherence tomography (AS-OCT).Design: Retrospective interventional case series.Participants: There were 22 eyes of 21 patients with conjunctival nevus imaged with AS-OCT for evaluation and detection of cysts within conjunctival nevi.Intervention: Anterior segment OCT.Main Outcome Measures: Evaluation and detection of intralesional cysts.Results: All margins of the nevus, including the deep margin, could be visualized on AS-OCT with high resolution of the anterior margin in 100% of cases, posterior margin in 82% of cases, and lateral margin in 86% of cases. The nevus was optically dense with homogeneous pattern in all cases. Some degree of deep optical shadowing, mostly from pigmented nevi, was noted in 86%. Intrinsic cysts within the nevus were detected by slit-lamp biomicroscopy in 18 cases (82%) and by AS-OCT in 17 cases (77%). In comparison with histopathologic findings, AS-OCT detected intrinsic cysts with a sensitivity of 80%, specificity of 100%, positive predictive value (PPV) of 100%, and negative predictive value (NPV) of 60%. Slit-lamp biomicroscopy (by experienced observers) compared with histopathology revealed detection of cysts with a sensitivity of 100%, a specificity of 100%, a PPV of 100%, and an NPV of 100%.Conclusions: Anterior segment OCT provides high-resolution imaging of conjunctival nevi with the ability to demonstrate all margins and to provide information on the presence of intralesional cysts, which are important in the diagnosis. The main drawback is optical shadowing of deeper structures from pigment within nevi.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2011; 118: 915-919 (C) 2011 by the American Academy of Ophthalmology.