Allograft inflammatory factor-1 in grass carp (Ctenopharynogodon idella): Expression and response to cadmium exposure.
Allograft inflammatory factor-1 in grass carp (Ctenopharynogodon idella): Expression and response to cadmium exposure.
复制标题
DOI：
10.1016/j.fsi.2015.08.034
复制
发表时间：
2015-11
影响因子：
4.7
通讯作者：
Yanying Zhao;Ruiwen Li;Yaqiu Lin
中科院分区：
文献类型：
--
作者：
Yanying Zhao;Ruiwen Li;Yaqiu Lin
同种异体炎症因子-1 （AIF-1）是一种主要由免疫细胞产生的炎症反应蛋白。AIF-1是一种促炎性细胞因子，是宿主免疫防御反应的关键调节因子。然而，AIF-1在淡水鱼中的炎症特性仍未被明确阐明。本研究从草鱼（Ctenopharynogodon idella）中鉴定出AIF-1。在脑、脾、肾、肝、心等组织中均有AIF-1的表达，而在红肌、鳃、胸腺、白肌、肠和鳍中表达量相对较低。在镉诱导下，AIF-1在脾脏中的转录和表达量下降，在肾脏中的表达量变化不大。结果表明，草鱼AIF-1可能参与镉胁迫。
Allograft Inflammatory Factor-1 (AIF-1) is an inflammation responsive protein that is mainly produced by immunocytes. As a pro-inflammatory cytokine, AIF-1 is a key moderator in host immune defense reaction. However, the inflammatory properties of AIF-1 in freshwater fish still hasn't been clearly elucidated. In the present study, AIF-1 was identified from grass carp (Ctenopharynogodon idella). It's transcript was found in all examined tissues including brain, spleen, kidney, liver, heart, while a relative low level in red muscle, gill, thymus, white muscle, intestine and fin. Furthermore, AIF-1 transcription and expression level decreased in spleen and didn't change a lot in kidney with cadmium induction, respectively. The result indicated that grass carp AIF-1 might be involved in cadmium-induced stress.