Synthesis of 2-(trifluoromethyl)oxazoles from β-monosubstituted enamines via PhI(OCOCF3)2-mediated trifluoroacetoxylation and cyclization.
Synthesis of 2-(trifluoromethyl)oxazoles from β-monosubstituted enamines via PhI(OCOCF3)2-mediated trifluoroacetoxylation and cyclization.
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DOI：
10.1021/jo202070h
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发表时间：
2011-11
期刊：
影响因子：
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通讯作者：
Feifei Zhao;Xin Liu;Rui Qi;D. Zhang-Negrerie;Jianhui Huang;Yunfei Du;K. Zhao
中科院分区：
文献类型：
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作者：
Feifei Zhao;Xin Liu;Rui Qi;D. Zhang-Negrerie;Jianhui Huang;Yunfei Du;K. Zhao
用苯基碘二（三氟乙酸酯）（PIFA）处理β-单取代胺可以得到各种4,5-二取代2-（三氟甲基）恶唑。这种方法允许将PIFA中的三氟甲基部分纳入最终产品，这可能是通过enamine底物的氧化β-三氟乙酰氧基化以及随后的分子内环化进行的。
Treatment of β-monosubstituted enamines with phenyliodine bis(trifluoroacetate) (PIFA) was found to give a variety of 4,5-disubstituted 2-(trifluoromethyl)oxazoles. This approach allows the incorporation of the trifluoromethyl moiety in PIFA into the final products, which presumably takes place via the oxidative β-trifluoroacetoxylation of the enamine substrates followed by subsequent intramolecular cyclization.