MICROMOLAR CALCIUM STIMULATES PROTEOLYSIS AND GLUTAMATE BINDING IN RAT-BRAIN SYNAPTIC-MEMBRANES
MICROMOLAR CALCIUM STIMULATES PROTEOLYSIS AND GLUTAMATE BINDING IN RAT-BRAIN SYNAPTIC-MEMBRANES
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DOI：
10.1126/science.7015504
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
LYNCH, GS
中科院分区：
文献类型：
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作者：
BAUDRY, M;BUNDMAN, MC;LYNCH, GS
孵育大鼠皮质突触膜与低浓度的钙导致的高分子量的双联体蛋白的量减少和增加的Na-独立的结合谷氨酸。巯基蛋白酶抑制剂亮抑酶肽阻断了这两种作用。钙诱导的膜组分的蛋白水解明显调节神经元膜中谷氨酸受体的数量。
Incubation of rat cortical synaptic membranes with low concentrations of Ca resulted in a decrease in the amount of a high-MW doublet protein and an increase in the Na-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. Ca-induced proteolysis of membrane components apparently regulates the number of glutamate receptors in neuronal membranes.