Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma
Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma
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DOI：
10.21037/qims.2018.09.09
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发表时间：
2018-09-01
影响因子：
2.8
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Fujima, Noriyuki;Hirata, Kenji;Shirato, Hiroki
背景资料：研究F-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描获得的定量形态学和肿瘤内特征的实用性（FDG-PET/CT）用于预测鼻腔或鼻窦鳞状细胞癌（SCC）患者的治疗结果。24例鼻腔或鼻窦鳞状细胞癌患者接受了非手术治疗（超选择动脉灌注顺铂联合放疗）进行回顾性分析。根据治疗前FDG-PET数据，分别计算肿瘤体积、表面积和球形度等13个定量形态学参数、肿瘤内特征（最大和平均标准摄取值、3个肿瘤内直方图和4个纹理参数）和总病变糖酵解（TLG）。关于治疗结果的信息由组织学诊断或临床随访确定。13个定量参数，以及T-和N-阶段的每一个进行了评估，其关系到局部控制或failure.Results的治疗结果：在单变量分析，局部控制和失败组之间的表面积和球度的显着差异进行了观察。受试者工作特征（ROC）曲线分析表明，球形度的准确度最高，为0.88。在多变量分析中，球形度被揭示为一个独立的预测局部控制或failure.Conclusions：球形度的定量参数是有用的，以预测治疗结果在鼻腔或鼻旁鳞状细胞癌患者。
Background: To investigate the utility of quantitative morphological and intratumoral characteristics obtained by F-18-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) for the prediction of treatment outcome in patients with nasal or paranasal cavity squamous cell carcinoma (SCC).Methods: Twenty-four patients with nasal or paranasal cavity SCC who received curative non-surgical therapy (a combination of super-selective arterial cisplatin infusion and radiotherapy) were retrospectively analyzed. From pre-treatment FDG-PET data, a total of 13 parameters of quantitative morphological characteristics (tumor volume, surface area and sphericity), intratumoral characteristics (the maximum and mean standard uptake value, three intratumoral histogram and four textural parameters) and total lesion glycolysis (TLG) were respectively calculated. Information regarding the treatment outcome was determined from the histological diagnosis or clinical follow-up. Each of the 13 quantitative parameters as well as T- and N-stage was assessed for its relation to treatment outcome of local control or failure.Results: In univariate analysis, significant differences in surface area and sphericity between the local control and failure groups were observed. The receiver operating characteristic (ROC) curve analysis showed that sphericity had the highest accuracy of 0.88. In the multivariate analysis, sphericity was revealed as an independent predictor of the local control or failure.Conclusions: The quantitative parameters of sphericity are useful to predict the treatment outcome in patients with nasal or paranasal SCC.