STEROID 11BETA-HYDROXYLASE ACTIVITY IN MICROSOMAL FRACTION OF HUMAN ADRENALS
STEROID 11BETA-HYDROXYLASE ACTIVITY IN MICROSOMAL FRACTION OF HUMAN ADRENALS
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DOI：
10.1016/0022-4731(76)90128-x
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发表时间：
1976-01-01
影响因子：
4.1
通讯作者：
ZACHMANN, M
中科院分区：
文献类型：
--
作者：
KLEIN, A;SIEBENMANN, R;ZACHMANN, M
在人肾上腺的20,000和105,000克组分中，测定了11-脱氧皮质醇和11-脱氧皮质酮(DOC)向其11β-羟化代谢物的转化。肾上腺取自肾移植供者。结果表明，微粒体组分中存在较高的11β-羟基酶活性，这不能归因于酶的污染。皮质醇的进一步代谢可能是通过17β-羟基类固醇侧链裂解酶来实现的。
The conversion of 11-deoxycortisol and 11-deoxycorticosterone (DOC) to their 11.beta.-hydroxylated metabolites was measured in the 20,000 and 105,000 g fractions of human adrenals. The adrenals were obtained from kidney transplantation donors. The results indicate the presence of relatively high 11.beta.-hydroxylase activity in the microsomal fraction which cannot be attributed to enzyme contamination. There would seem to be further metabolism of cortisol probably by an 17.beta.-hydroxysteroid side chain cleavage enzyme.