Dystrophic microglia in the aging human brain
Dystrophic microglia in the aging human brain
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DOI：
10.1002/glia.10319
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发表时间：
2004-01-15
期刊：
影响因子：
6.2
通讯作者：
Sparks, DL
中科院分区：
文献类型：
--
作者：
Streit, WJ;Sammons, NW;Sparks, DL
我们用高分辨率LN-3免疫组织化学方法研究了两名非痴呆受试者大脑皮层小胶质细胞的形态。在小胶质细胞胞浆结构中发现了几种异常，包括去角质化、球体形成、节状和突起碎裂。这些变化被确定为不同于小胶质细胞激活时的形态变化，它们被统称为小胶质细胞营养不良。对小胶质细胞营养不良改变的定量评估显示，这些变化在老年受试者(68岁)中比年轻受试者(38岁)中更常见。因此，我们得出结论，小胶质细胞营养不良是小胶质细胞衰老的标志。我们假设，小胶质细胞衰老对于理解与年龄相关的认知功能下降可能是重要的。(C)2003年Wiley-Liss，Inc.
We have studied microglial morphology in the human cerebral cortex of two nondemented subjects using high-resolution LN-3 immunohistochemistry. Several abnormalities in microglial cytoplasmic structure, including deramification, spheroid formation, gnarling, and fragmentation of processes, were identified. These changes were determined to be different from the morphological changes that occur during microglial activation and they were designated collectively as microglial dystrophy. Quantitative evaluation of dystrophic changes in microglia revealed that these were much more prevalent in the older subject (68-year-old) than in the younger one (38-year-old). Thus, we conclude that microglial dystrophy is a sign of microglial cell senescence. We hypothesize that microglial senescence could be important for understanding age-related declines in cognitive function. (C) 2003 Wiley-Liss, Inc.