An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201
An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201
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DOI：
10.1017/s1461145798001023
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发表时间：
1998-07-01
影响因子：
4.8
通讯作者：
Brautbar, C
中科院分区：
文献类型：
--
作者：
Amar, A;Segman, RH;Brautbar, C
一组18名以色列，氯氮平治疗，精神分裂症患者进行分子和血清学HLA分型，以确定是否主要组织相容性复合体与氯氮平诱导的粒细胞缺乏症的发展。在氯氮平治疗期间，18例患者中有2例发生粒细胞缺乏症（总白色血细胞计数< 3000/mm（3）和绝对多形细胞计数< 500/mm（3）），3例发生粒细胞减少症（总白色血细胞计数< 3500/mm（3）和绝对多形细胞计数< 1000/mm（3））。HLA-DQBI*0201存在于所有发生粒细胞缺乏症或粒细胞减少症的Eve患者中（5/5; 100%），但只有54%（7/13）的患者没有发生这些并发症。这些结果表明，DQBI*0201或位于附近的基因可能参与氯氮平诱导的粒细胞缺乏症。
A group of 18 Israeli, clozapine-treated, schizophrenia patients underwent molecular and serological HLA typing in order to determine whether the major histocompatibility complex is associated with the development of clozapine-induced agranulocytosis. While under treatment with clozapine, 2 of the 18 patients developed agranulocytosis (total white blood cell count < 3000/mm(3) and absolute polymorphonuclear count < 500/mm(3)) and 3 developed granulocytopenia (total white blood cell count < 3500/mm(3) and absolute polymorphonuclear count < 1000/mm(3)). HLA-DQBI*0201 was present in all Eve patients who developed agranulocytosis or granulocytopenia (5/5; 100%), but in only 54% (7/13) of the patients who did not develop those complications. These findings indicate that DQBI*0201 or a gene located nearby could be involved in clozapine-induced agranulocytosis.