Parent-Offspring Body Mass Index Associations in the Norwegian Mother and Child Cohort Study: A Family-based Approach to Studying the Role of the Intrauterine Environment in Childhood Adiposity
Parent-Offspring Body Mass Index Associations in the Norwegian Mother and Child Cohort Study: A Family-based Approach to Studying the Role of the Intrauterine Environment in Childhood Adiposity
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DOI：
10.1093/aje/kws134
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发表时间：
2012-07-15
影响因子：
5
通讯作者：
Naess, Oyvind
中科院分区：
文献类型：
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作者：
Fleten, Caroline;Nystad, Wenche;Naess, Oyvind
在本研究中，作者研究了宫内环境在儿童肥胖中的作用，通过比较母亲-子女体重指数（BMI）与3岁时父母-子女BMI的关系，使用父母孕前BMI（测量为体重（kg）除以身高（m）的平方）。2001年至2008年期间，在挪威公共卫生研究所进行的挪威母亲和儿童队列研究中招募了父母-子女三人组（n 29，216）。自填问卷的数据用于线性回归分析。粗分析显示了相似的父母-子女BMI相关性;母亲BMI每增加1个标准差，子女BMI的平均差异为0.15（95置信区间：0.13，0.16），父亲BMI每增加1个标准差，子女BMI的平均差异为0.15（95置信区间：0.13，0.17）。所有调整后，母亲BMI每增加1个标准差，后代BMI的平均差异为0.12，父亲BMI每增加1个标准差，后代BMI的平均差异为0.13。没有强有力的证据支持相关性之间的异质性（P 0.6）。总之，本大规模人群研究的结果显示，当后代3岁时，父母-后代BMI相关性相似，这表明母亲-后代相关性可能由共同的家族（环境和遗传）风险因素而不是宫内环境解释。
In the present study, the authors investigated the role of the intrauterine environment in childhood adiposity by comparing the maternal-offspring body mass index (BMI) association with the paternal-offspring BMI association when the offspring were 3 years of age, using parental prepregnancy BMI (measured as weight in kilograms divided by height in meters squared). The parent-offspring trios (n 29,216) were recruited during pregnancy from 2001 to 2008 into the Norwegian Mother and Child Cohort Study conducted by The Norwegian Institute of Public Health. Data from self-administered questionnaires were used in linear regression analyses. Crude analyses showed similar parental-offspring BMI associations; the mean difference in offspring BMI was 0.15 (95 confidence interval: 0.13, 0.16) per each 1-standard-deviation increase in maternal BMI and 0.15 (95 confidence interval: 0.13, 0.17) per each 1-standard-deviation increase in paternal BMI. After all adjustments, the mean difference in offspring BMI per each 1-standard-deviation increment of maternal BMI was 0.12, and the mean difference in offspring BMI per each 1-standard-deviation increment of paternal BMI was 0.13. There was no strong support for heterogeneity between the associations (P 0.6). In conclusion, results from the present large population-based study showed similar parental-offspring BMI associations when the offspring were 3 years of age, which indicates that the maternal-offspring association may be explained by shared familial (environmental and genetic) risk factors rather than by the intrauterine environment.