Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.
Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.
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DOI：
10.1530/eje.1.02171
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发表时间：
2006-07
影响因子：
5.8
通讯作者：
Dae-Yeol Lee;Sun-Young Kim;D. Jo;P. Hwang;K. P. Kang;Sik Lee;Won Kim;S. K. Park
中科院分区：
文献类型：
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作者：
Dae-Yeol Lee;Sun-Young Kim;D. Jo;P. Hwang;K. P. Kang;Sik Lee;Won Kim;S. K. Park
目的Ghrelin是一种新的肽类激素，具有促生长、促食欲和促脂肪生成的作用。最近的研究表明，Preproghrelin Leu 72 Met多态性与2型糖尿病患者的血清肌酐（Scr）浓度相关;与72 Met非携带者相比，72 Met携带者的Scr水平较低。我们假设前促生长素原Leu 72 Met多态性与2型糖尿病肾病患者发生肾功能不全的发生率较低相关。设计采用PCR技术对138例糖尿病肾病患者（分为肾功能正常组和肾功能不全组）的前促生长素原Leu 72 Met基因多态性进行研究。方法测定前促生长素原Leu 72 Met多态性的频率是主要的结果指标。结果糖尿病肾病患者Leu 72 Met基因多态性频率（15.9%，P < 0.01）明显低于肾功能正常组（42.0%，P < 0.01）和糖尿病对照组（40.6%，P <0.01）。Leu 72 Met基因多态性也与糖尿病肾病肾功能不全患者血清总胆固醇水平相关，72 Met基因携带者血清总胆固醇水平低于72 Met基因非携带者（P < 0.05）。结论72 Met携带状态可作为糖尿病肾病发生肾功能损害的一个预测指标。
OBJECTIVE Ghrelin is a novel peptide hormone, which exerts somatotropic, orexigenic and adipogenic effects. Recent studies have shown that the preproghrelin Leu72Met polymorphism is associated with serum creatinine (Scr) concentration in type 2 diabetes; 72Met carriers exhibited lower Scr levels as compared with the 72Met non-carriers. We hypothesized that the preproghrelin Leu72Met polymorphism is associated with a lower rate of developing renal dysfunction in patients with type 2 diabetic nephropathy. DESIGN The preproghrelin Leu72Met polymorphism was investigated using PCR techniques in 138 patients with diabetic nephropathy divided into two groups, one with normal renal function and the other with renal dysfunction. METHODS Determination of the frequency of the preproghrelin Leu72Met polymorphism was the main outcome measure. RESULTS The frequency of the Leu72Met polymorphism in diabetic nephropathy was significantly lower in patients with renal dysfunction (15.9%, P < 0.01) than in patients with normal renal function (42.0%) or in the diabetes control group (40.6%). The Leu72Met polymorphism was also associated with serum total cholesterol levels in diabetic nephropathy patients with renal dysfunction; the 72Met carriers had lower total cholesterol levels than the 72Met non-carriers (P < 0.05). CONCLUSION These data suggest that 72Met carrier status may be used as a marker predicting a lower chance of developing renal dysfunction in diabetic nephropathy.