Silicon-on-Glass Graphene-Functionalized Leaky Cavity Mode Nanophotonic Biosensor
Silicon-on-Glass Graphene-Functionalized Leaky Cavity Mode Nanophotonic Biosensor
复制标题
玻璃上硅石墨烯功能化漏腔模式纳米光子生物传感器
DOI：
10.1021/ph400073w
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发表时间：
2014-03-01
期刊：
影响因子：
7
通讯作者：
Cubukcu, Ertugrul
中科院分区：
文献类型：
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作者：
Guo, Qiushi;Zhu, Hai;Cubukcu, Ertugrul
已知亚波长硅纳米结构支持高度局部化的共振光学模式。这些共振在频谱上是窄的，具有显著延伸到周围介质中的电磁近场。在这里，我们证明了周期性硅纳米线阵列中的漏腔模式共振（LCMR）可以作为低成本，无标记和高灵敏度生物传感的平台，并建立了与实验结果一致的LCMR现象的理论框架。该传感器具有体积折射率灵敏度高达213 nm/RIU。此外，通过用石墨烯单层功能化硅纳米结构的表面，这种结构可以用于光学检测低浓度表面吸附事件。使用免疫球蛋白G蛋白（IgG）的特定的无标记检测限被发现是在300 pM的顺序与提取的最大传感器共振位移为5.42 nm。这种传感平台具有解开蛋白质蛋白质相互作用的重大承诺，并提供了独特的机会，在一个单一的硅光子芯片上实现激光传感。
Subwavelength silicon nanostructures are known to support highly localized resonant optical modes. These resonances are spectrally narrow with an electromagnetic near-field that extends significantly into the surrounding medium. Here, we demonstrate that leaky cavity mode resonances (LCMR) in periodic silicon nanowire arrays can serve as a platform for low-cost, label-free, and highly sensitive biosensing and establish a theoretical framework for the LCMR phenomenon that is consistent with experimental results. The sensors exhibit bulk refractive index sensitivities up to 213 nm/RIU. Moreover, by functionalizing the surface of silicon nanostructures with a graphene monolayer, such structures can be used to optically detect low-concentration surface adsorption events. The specific label-free detection limit using immunoglobulin G protein (IgG) is found to be on the order of 300 pM with an extracted maximum sensor resonance shift of 5.42 nm. This sensing platform holds significant promise for unraveling protein protein interactions and offers unique opportunities for implementation of laser sensing on a single silicon photonic chip.