Lysosomes and microtubules as targets for photochemotherapy of cancer
Lysosomes and microtubules as targets for photochemotherapy of cancer
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DOI：
10.1111/j.1751-1097.1997.tb08578.x
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发表时间：
1997-03-01
影响因子：
3.3
通讯作者：
Moan, J
中科院分区：
文献类型：
--
作者：
Berg, K;Moan, J
在实验和临床光化学疗法（PCT）中使用的大多数光敏剂？光动力疗法（PDT）的作用主要集中在细胞的胞核周围：质膜、线粒体、内质网、高尔基体和溶酶体。细胞内定位取决于敏化剂的化学性质，即其疏水性、电荷和两亲性（1）。细胞内定位似乎也在一定程度上依赖于细胞系。负责光化学诱导的细胞死亡的细胞内靶标的身份取决于上述参数。将讨论溶酶体和微管（MT）作为培养细胞的光化学处理目标的特殊情况。
Most of the photosensitizers used in experimental and clinical photochemotherapy (PCT)? of cancer (ie photodynamic therapy [PDT]) localize extranuclearly in cells: in the plasma membrane, in mitochondria, in endoplasmic reticulum, in Golgi apparatus and in lysosomes. The intracellular localization is dependent upon the chemical properties of the sensitizer, ie its hydrophobicity, charge and amphiphilic character (1). The intracellular localization seems also to be to some extent cell line dependent. The identity of the intracellular targets responsible for photochemically induced cell death depends on the parameters mentioned above. The special cases of lysosomes and microtubules (MT) as targets for photochemical treatment of cells in culture will be discussed.