Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy
Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy
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DOI：
10.1159/000088382
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Uji, Y
中科院分区：
文献类型：
--
作者：
Sugimoto, M;Sasoh, M;Uji, Y
目的：采用光学相干断层扫描（OCT）检测无糖尿病视网膜病变（NDR）的2型糖尿病患者的早期糖尿病损害，并评价OCT作为临床试验的价值。方法：选择32例NDR患者。我们用OCT检查了视网膜和视网膜神经纤维层（RNFL）的厚度。两个健康的正常人群也被纳入了视网膜厚度（n = 48）和RNFL厚度（n = 34）。在四个区域（颞、上级、鼻和下）获得两个OCT测量值。生成受试者工作特征（ROC）曲线以评估预测变量。结果如下：比较正常眼和NDR眼，视网膜厚度显著增加（p = 0.03），RNFL厚度显著减少（p = 0.02），在上级区域。上级视网膜厚度的ROC曲线下面积为0.65，上级RNFL厚度的ROC曲线下面积为0.63。结论：两种OCT测量方法均可检测NDR患者的早期视网膜损伤。版权所有（c）2005 S. Karger AG，巴塞尔。
Purpose: To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy ( NDR) using optical coherence tomography ( OCT) and to evaluate OCT as a clinical test. Methods: Thirty-two patients with NDR ( n = 32) were enrolled. We examined retinal and retinal nerve fiber layer ( RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness ( n = 48) and RNFL thickness ( n = 34). Both OCT measurements were obtained in four areas ( temporal, superior, nasal and inferior). The receiver operator characteristic ( ROC) curve was generated to evaluate the predictor variables. Results: Comparing the normal and NDR eyes, retinal thickness significantly increased ( p = 0.03) and RNFL thickness significantly decreased ( p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness. Conclusions: Both OCT measurements can detect early retinal damage in NDR patients. Copyright (c) 2005 S. Karger AG, Basel.