Ultrashort echo time imaging with bicomponent analysis
Ultrashort echo time imaging with bicomponent analysis
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DOI：
10.1002/mrm.23047
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Bydder, Graeme M.
中科院分区：
文献类型：
--
作者：
Du, Jiang;Diaz, Eric;Bydder, Graeme M.
生物组织通常含有不同的水室，这些水室通常有不同的横向松弛时间。在临床扫描仪上量化这些可能会有问题，因为自旋回波序列的初始回波时间通常太长，无法准确量化较短的松弛时间成分。在本研究中，超短回波时间脉冲序列与双组分分析一起用于量化肌肉骨骼系统组织中的短和长T2组分。可行性研究采用数值模拟、模型和体外组织进行，包括牛皮质骨、韧带、半月板、肌腱和关节软骨。仿真和模拟研究表明，该技术可以量化T2*和短分量和长分量的分数。组织研究显示两种不同的成分：短T2*s，从牛皮质骨的0.3 ms到半月板的2.1 ms；长T2*s，从牛皮质骨的2.9 ms到关节软骨的35.0 ms。短T2*分数从髌骨软骨18.5%到韧带80.9%不等。结果表明，采用双组分分析的超短回波时间成像技术可以定量测定肌肉骨骼组织中短、长T2水组分。《理性医学杂志》，2012。(c) 2011 Wiley期刊公司
Biological tissues frequently contain different water compartments, and these often have distinct transverse relaxation times. Quantification of these may be problematic on clinical scanners because spin echo sequences usually have initial echo times that are too long to accurately quantify shorter relaxation time components. In this study, an ultrashort echo time pulse sequence was used together with bicomponent analysis to quantify both the short and long T2 components in tissues of the musculoskeletal system. Feasibility studies were performed using numerical simulation, and on phantoms and in vitro tissues including bovine cortical bone, ligaments, menisci, tendons, and articular cartilage. The simulation and phantom studies demonstrated that this technique can quantify T2* and fractions of the short and long T2 components. The tissues studies showed two distinct components with short T2*s ranging from 0.3 ms for bovine cortical bone to 2.1 ms for menisci, and long T2*s ranging from 2.9 ms for bovine cortical bone to 35.0 ms for articular cartilage. The short T2* fraction ranged from 18.5% for patella cartilage to 80.9% for ligaments. The results show that ultrashort echo time imaging with bicomponent analysis can quantify the short and long T2 water components in vitro in musculoskeletal tissues. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.