Cutaneous Presentation of Mesothelioma With a Sarcomatoid Transformation.
Cutaneous Presentation of Mesothelioma With a Sarcomatoid Transformation.
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间皮瘤伴肉瘤样转化的皮肤表现。
DOI：
10.1097/dad.0000000000001023
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Tsao,Hensin
中科院分区：
文献类型：
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作者：
Klebanov,Nikolai;Reddy,BobbyY;Husain,Sameera;Silvers,DavidN;Grossman,MarcE;Tsao,Hensin
恶性胸膜间皮瘤是一种罕见的起源于中胚层的肿瘤。恶性胸膜间皮瘤的皮肤累及是一个非常罕见的实体，只有11例文献报道。在这里，我们描述了一个75岁的男性IV期上皮样胸膜间皮瘤的病例，在最初诊断后5个月出现皮肤爆发，皮肤活检显示出肉瘤样特征。通过胸膜、淋巴结和皮肤组织的免疫组化染色对恶性肿瘤进展进行组织学分析，发现calcaltin逐渐减少，desmin增加，支持从上皮样组织向肉瘤样组织的转化。据我们所知，这是第一例以皮肤为表现的恶性胸膜间皮瘤上皮样向肉瘤样转化的报道。
Malignant pleural mesothelioma is a rare neoplasm of mesodermal origin. Cutaneous involvement of malignant pleural mesothelioma is a very rare entity, with only 11 cases reported in the literature. Here, we describe the case of a 75-year-old man with stage IV epithelioid pleural mesothelioma, presenting with a cutaneous eruption 5 months after initial diagnosis, which revealed sarcomatoid features on skin biopsy. Histological analysis of malignancy progression through immunohistochemical staining of the pleural, lymph node, and skin tissue revealed gradual loss of calretinin and gain of desmin, supporting a transformation from epithelioid to sarcomatoid tissue. To our knowledge, this is the first reported case of an epithelioid to sarcomatoid transformation of malignant pleural mesothelioma manifesting in a cutaneous presentation.