Inverse relation of serum Helicobacter pylori antibody titres and extent of intestinal metaplasia.
Inverse relation of serum Helicobacter pylori antibody titres and extent of intestinal metaplasia.
复制标题
血清幽门螺杆菌抗体滴度与肠化生程度呈反比关系。
DOI：
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发表时间：
1996
影响因子：
3.4
通讯作者：
Y. Yoshida
中科院分区：
文献类型：
--
作者：
H. Osawa;F. Inoue;Y. Yoshida
目标：目的：探讨血清抗幽门螺杆菌（H pylori）抗体滴度与胃粘膜肠上皮化生程度的关系。方法：对95例接受年度健康检查的无症状个体（平均年龄65岁）的血清抗幽门螺杆菌IgG滴度进行测量，并与通过检查多个内镜粘膜活检标本确定的肠上皮化生程度（无、中度或广泛）进行比较。血清胃蛋白酶原I（PGI）水平，作为胃萎缩的标志物，也进行了测量。结果：无论化生的程度如何，幽门螺杆菌抗体的血清阳性率都很高（> 80%）。然而，化生程度与抗幽门螺杆菌滴度之间存在负相关性：无化生组中75%的受试者具有高（3+）抗体水平，中度化生组中43%的受试者具有高（3+）抗体水平，广泛化生组中37%的受试者具有高（3+）抗体水平。当在PGI正常（> 30 ng/ml）的受试者中检查时，滴度和化生程度之间的负相关性是明显的，而在PGI低（≤ 30 ng/ml）的受试者中没有这种关系。结论：抗幽门螺杆菌滴度与肠上皮化生程度呈负相关，特别是在胃萎缩不明显的受试者中。
AIMS: To clarify the relation between the serum titre of anti-Helicobacter pylori (H pylori) antibody and the extent of intestinal metaplasia of the gastric mucosa. METHODS: The serum anti-H pylori IgG titres of 95 asymptomatic individuals (mean age 65 years) undergoing an annual health examination were measured and compared with the extent of intestinal metaplasia (absent, moderate, or extensive), determined by examination of multiple endoscopic mucosal biopsy specimens. Serum pepsinogen I (PGI) levels, as a marker for gastric atrophy, were also measured. RESULTS: The prevalence of seropositivity for H pylori antibody was high (> 80%), regardless of the extent of metaplasia. However, there was a negative association between the extent of metaplasia and the anti-H pylori titre: 75% of the subjects in the group without metaplasia had high (3+) antibody levels, as did 43% with moderate, and 37% with extensive metaplasia (absent v extensive). The inverse relation between the titre and the extent of metaplasia was evident when examined in those with normal PGI (> 30 ng/ml), whereas no such relation was apparent in subjects with low PGI (< or = 30 ng/ml). CONCLUSIONS: The anti-H pylori titre correlates inversely with the extent of intestinal metaplasia, particularly in subjects with less marked gastric atrophy.
影响因子：
5
作者：
STEMMERMANN, GN;SAMLOFF, IM;HEILBRUN, LK
通讯作者：
HEILBRUN, LK