Role of CBP/P300 in nuclear receptor signalling
Role of CBP/P300 in nuclear receptor signalling
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DOI：
10.1038/383099a0
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发表时间：
1996-09-05
期刊：
影响因子：
64.8
通讯作者：
Evans, RM
中科院分区：
文献类型：
--
作者：
Chakravarti, D;LaMorte, VJ;Evans, RM
核受体超家族包括类固醇、类维生素a、甲状腺激素和维生素D以及许多相关蛋白质的受体（1-3）。亲脂激素和维生素作用的一个重要特征是，维持体内平衡功能需要内在的正调节和负调节（4,5）。在这里，我们提供了体外和体内证据，证明creb结合蛋白（CBP）及其同源物P300（参考文献6,7）是介导核受体激活基因转录的辅助因子。CBP/P300在对环AMP、酚酯、血清、亲脂激素的转录反应中的作用，以及作为E1A癌蛋白的靶标，表明它们可能是细胞外和细胞内信号通路的整合者。
THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins(1-3). An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation(4,5). Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.