On the mechanism of immunologic self recognition.
On the mechanism of immunologic self recognition.
复制标题
免疫学自我识别机制研究.
DOI：
10.4049/jimmunol.89.4.505
复制
发表时间：
1962
影响因子：
4.4
通讯作者：
Edward L. Triplett
中科院分区：
文献类型：
--
作者：
Edward L. Triplett
已有实验表明，免疫系统识别自我的能力是在发育过程中通过接触自身组织的抗原决定簇而获得的获得性属性。实验首先在腺体分化之前(开始产生成体类型的蛋白质)但在腺体确定(具有自我分化的能力)之后的发育阶段去除脑下垂体的口腔部分，然后将有机体和腺体分开生长，直到有机体在免疫上成熟，腺体分化。然后，将腺体和有机体作为移植物和宿主结合在一起。在相当大比例的情况下，这种动物排斥自己的脑下垂体。对照实验排除了移植物的抗原性改变或动物失去接受自体移植物的能力的可能性。
Experiments have been performed which indicate that the ability of the immune system to recognize self is an acquired property gained by contacting antigenic determinants of self tissues at some time during development. The experiments consisted first of removing the buccal component of the pituitary gland at a stage in development before the gland had differentiated (begun to produce adult type proteins) but after the gland had been determined (possessed the ability to self-differentiate) and then growing the organism and the gland apart from one another until the organism was immunologically mature and the gland was differentiated. The gland and organism were then brought together as graft and host. In a significant percentage of cases the animal rejected its own hypophysis. Control experiments excluded the possibility that the antigenicity of the graft had changed or that the animals had lost the ability to accept autografts.