Autophagy impairment: a crossroad between neurodegeneration and tauopathies.
Autophagy impairment: a crossroad between neurodegeneration and tauopathies.
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DOI：
10.1186/1741-7007-10-78
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发表时间：
2012-09-21
期刊：
影响因子：
5.4
通讯作者：
Hetz C
中科院分区：
文献类型：
--
作者：
Nassif M;Hetz C
大多数神经退行性疾病涉及神经系统中错误折叠蛋白质的积累。蛋白质降解途径的损伤，如自噬，正在成为神经退行性疾病（包括阿尔茨海默氏病、亨廷顿氏病和帕金森病）中一致和横向的病理现象。小鼠自噬基因失活在维持脑内蛋白质稳态、引发大量神经元丢失和异常蛋白包涵体积累方面发挥了关键作用。然而，自噬损伤引起的神经退行性变的机制尚不清楚。Abeliovich小组发表在《Molecular Neurodegeneration》杂志上的一篇论文现在提出了Tau磷酸化和糖原合成酶激酶3β (GSK3β)的激活在驱动自噬缺陷神经元的神经退行性变中的作用。我们讨论了这项研究对理解阿尔茨海默病和牛头病变中驱动神经原纤维缠结形成的因素的意义。参见研究文章http://www.molecularneurodegeneration.com/content/7/1/48
Most neurodegenerative diseases involve the accumulation of misfolded proteins in the nervous system. Impairment of protein degradation pathways such as autophagy is emerging as a consistent and transversal pathological phenomenon in neurodegenerative diseases, including Alzheimer's, Huntington's, and Parkinson's disease. Genetic inactivation of autophagy in mice has demonstrated a key role of the pathway in maintaining protein homeostasis in the brain, triggering massive neuronal loss and the accumulation of abnormal protein inclusions. However, the mechanism underlying neurodegeneration due to autophagy impairment remains elusive. A paper in Molecular Neurodegeneration from Abeliovich's group now suggests a role for phosphorylation of Tau and the activation of glycogen synthase kinase 3β (GSK3β) in driving neurodegeneration in autophagy-deficient neurons. We discuss the implications of this study for understanding the factors driving neurofibrillary tangle formation in Alzheimer's disease and tauopathies. See research article http://www.molecularneurodegeneration.com/content/7/1/48
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DOI：
10.1093/brain/aws143
发表时间：
2012-07
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Schaeffer V;Lavenir I;Ozcelik S;Tolnay M;Winkler DT;Goedert M
通讯作者：
Goedert M
影响因子：
14.5
作者：
Yang, Dun-Sheng;Stavrides, Philip;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
影响因子：
7.5
作者：
Matus, Soledad;Glimcher, Laurie H.;Hetz, Claudio
通讯作者：
Hetz, Claudio
影响因子：
64.8
作者：
Komatsu, Masaaki;Waguri, Satoshi;Tanaka, Keiji
通讯作者：
Tanaka, Keiji
影响因子：
11.2
作者：
Jucker, Mathias;Walker, Lary C.
通讯作者：
Walker, Lary C.