Stably-dispersed and Surface-functional Bionanoparticles Prepared by Self-assembling Amphipathic Polymers of Hydrophilic Poly(γ-glutamic acid) Bearing Hydrophobic Amino Acids
Stably-dispersed and Surface-functional Bionanoparticles Prepared by Self-assembling Amphipathic Polymers of Hydrophilic Poly(γ-glutamic acid) Bearing Hydrophobic Amino Acids
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DOI：
10.1246/cl.2004.398
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发表时间：
2004-03
影响因子：
1.6
通讯作者：
MatsusakiMichiya;HiwatariKen-ichiro;HigashiMariko;KanekoTatsuo;AkashiMitsuru
中科院分区：
文献类型：
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作者：
MatsusakiMichiya;HiwatariKen-ichiro;HigashiMariko;KanekoTatsuo;AkashiMitsuru
通过自组装两亲性聚γ-谷氨酸衍生物，制备了表面功能化的生物纳米粒子。聚γ-谷氨酸苯丙氨酸纳米球具有良好的亲水性、表面功能性和适宜的粒径（200 nm）。添加剂PEG缀合辅助亮氨酸接枝的聚（γ-谷氨酸）的纳米颗粒形成。
Surface-functional bionanoparticles were prepared by self-assembling amphipathic poly(y-glutamic acid) derivatives with a hydrophilic backbone and hydrophobic phenylalanine and leucine side groups. Poly(y-glutamic acid) bearing phenylalanine nanospheres exhibited excellent water-dispersibility, surface functionality and appropriate size (200 nm) for medical use. Additive PEG conjugation assisted nanoparticle formation of leucine-grafted poly(y-glutamic acid).