Fine Regulation of Porous Architectures of Core-Shell Silica Nanocomposites Offers Robust Nanoprobes with Accelerated Responsiveness
Fine Regulation of Porous Architectures of Core-Shell Silica Nanocomposites Offers Robust Nanoprobes with Accelerated Responsiveness
复制标题
核壳二氧化硅纳米复合材料的多孔结构的精细调控提供了具有加速响应能力的鲁棒纳米探针
DOI：
10.1021/acsami.7b11226
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发表时间：
2017
影响因子：
9.5
通讯作者：
Zhao Chunchang
中科院分区：
文献类型：
--
作者：
Shi Ben;Gu Xianfeng;Wang Zhijun;Xu Ge;Fei Qiang;Tang Jie;Zhao Chunchang
具有良好的水溶性和生物相容性以及快速响应的探针可以作为评估药物内源性产生H_2S的潜在分子机制的理想工具；然而，它们仍然缺乏，但非常可取。在这里，我们展示了一种新的策略，通过在水分散的核壳结构的二氧化硅纳米颗粒中锁定Fö共振能量转移硼二吡咯亚甲基对来构建高效的硫化氢纳米探针。重要的是，由于屏蔽层的存在，这些纳米复合材料可以有效地将互补客体限制在相同的核心内，从而保证高效的Fö共振能量转移。有趣的是，这种纳米粒子的内部微环境可以通过硅烷化试剂进行调节。这样，通过优化硅烷化试剂的用量和极性有机基团的用量，建立了一种理想的探针，可以快速、定量地检测15 S范围内的硫化氢。显然，硅烷化试剂不仅是一个建立坚固结构的平台，而且还可以优化内部的微环境，提供理想的探针。这些二氧化硅纳米复合材料也被成功地用于揭示雌激素诱导心肌细胞内源性硫化氢的产生。
Probes bearing good aqueous solubility and biocompatibility as well as fast response can serve as ideal tools for evaluating the underlying molecular mechanism of endogenous production of H2S caused by drugs; however, they are still lacking but highly desirable. Here, we demonstrate a novel strategy for constructing highly efficient H2S nanoprobes through locking Förster resonance energy transfer borondipyrromethene (BODIPY) pairs in water-dispersible core–shell silica nanoparticles. Importantly, these nanocomposites can effectively confine complementary guests within the same cores due to the existence of a shield, thus guaranteeing efficient Förster resonance energy transfer. Interestingly, the interior microenvironment of such nanoparticles could be tuned by silylation agents. In this way, an ideal probe for rapid and ratiometric detection of H2S within 15 s is established by optimizing the amount of silylation agent with a polar organic group. Obviously, the silylation agents are explored to serve as a platform not only for establishment of robust structures but also for optimizing the microenvironment of the interior to afford an ideal probe. These silica nanocomposites have also been successfully employed in disclosing the endogenous production of H2S induced by estrogen in cardiomyocytes.