Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging
Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging
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DOI：
10.1002/(sici)1097-0193(1997)5:2
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发表时间：
1997-01-01
影响因子：
4.8
通讯作者：
Rosen, BR
中科院分区：
文献类型：
--
作者：
Rauch, SL;Whalen, PJ;Rosen, BR
先前的研究反复暗示纹状体参与内隐序列学习；然而，影像学结果对涉及的分区域和侧边尚无定论。利用功能性磁共振成像（fMRI）技术，研究了10名正常右撇子男性在完成系列反应时间任务（SRT）时的脑活动特征。行为学结果表明，显著内隐学习的发生并未受到显著外显知识的影响。来自整个队列的串联功能磁共振成像数据显示，尾状核和壳核的右侧激活都很明显。对来自个体受试者的功能磁共振成像数据的分析显示，涉及的精确区域（包括左尾状核和右壳核）在个体之间存在差异。有趣的是，所有表现出强大学习效果的7名受试者在壳核内都表现出显著的激活。此外，在7名被试中，壳核内信号强度变化的大小与获得的反应时间优势的大小显著相关。这些发现表明，在内隐序列学习过程中，受试者的右侧纹状体被激活，但也强调了涉及的侧性和纹状体亚区域的个体间差异。具体而言，来自个体受试者的结果表明，在SRT过程中，通过内隐序列学习获得的反应时间优势可能主要与壳核内的活动有关。(C) 1997 Wiley-Liss, Inc。
Prior research has repeatedly implicated the striatum in implicit sequence learning; however, imaging findings have been inconclusive with respect to the sub-territories and laterality involved. Using functional magnetic resonance imaging (fMRI), we studied brain activation profiles associated with performance of the serial reaction time task (SRT) in 10 normal right-handed males. Behavioral results indicate that significant implicit learning occurred, uncontaminated by significant explicit knowledge. Concatenated fMRI data from the entire cohort revealed significant right-lateralized activation in both the caudate and putamen. Analysis of fMRI data from individual subjects showed inter-individual variability as to the precise territories involved, including right as well as left caudate and putamen. Interestingly, all seven subjects who manifested robust learning effects exhibited significant activation within the putamen. Moreover, among those seven subjects, the magnitude of signal intensity change within the putamen correlated significantly with the magnitude of reaction time advantage achieved. These findings demonstrate right-sided striatal activation across subjects during implicit sequence learning, but also highlight interindividual variability with respect to the laterality and striatal subterritories involved. In particular, results from individual subjects suggest that, during the SRT, the reaction time advantage garnered via implicit sequence learning might be predominantly associated with activity within the putamen. (C) 1997 Wiley-Liss, Inc.