Vocal Training Mitigates Age-Related Changes Within the Vocal Mechanism in Old Rats
Vocal Training Mitigates Age-Related Changes Within the Vocal Mechanism in Old Rats
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DOI：
10.1093/gerona/glt044
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发表时间：
2013-12-01
影响因子：
5.1
通讯作者：
Connor, Nadine P.
中科院分区：
文献类型：
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作者：
Johnson, Aaron M.;Ciucci, Michelle R.;Connor, Nadine P.
衰老会影响声音的产生，并与沟通能力和生活质量下降有关。声音治疗是治疗的一个重要组成部分，但其对神经肌肉机制的影响尚不清楚。大鼠超声发声（USV）可以用来检测年龄和发声对喉神经肌肉系统的影响。本研究验证了大鼠USV和喉神经肌肉接头的年龄相关变化可以通过发声练习逆转的假设。年轻和老年大鼠训练8周以增加其USV，并与治疗前和治疗后的无干预组进行比较。在甲杓肌中测量USV声学和神经肌肉接头（NMJ）形态学方面。声乐训练减少或消除了USV和NMJ的一些年龄差异。我们的结论是，发声练习可能有助于减轻年龄相关的声音特征和神经肌肉适应的变化。
Aging affects voice production and is associated with reduced communicative ability and quality of life. Voice therapy is a critical component of treatment, but its effects on neuromuscular mechanisms are unknown. The ultrasonic vocalizations (USVs) of rats can be used to test the effects of aging and voice use on the laryngeal neuromuscular system. This study tested the hypothesis that age-related changes in the USVs of rats and laryngeal neuromuscular junctions can be reversed through vocal exercise. Young and old rats were trained for 8 weeks to increase their USVs and were compared with a no intervention group pre- and post-treatment. USV acoustics and aspects of neuromuscular junction (NMJ) morphology were measured in the thyroarytenoid muscle. Vocal training reduced or eliminated some age differences found in both USVs and NMJs. We conclude that vocal exercise may assist in mitigating age-related changes in voice characteristics and underlying neuromuscular adaptations.