Energy restriction and the risk of spontaneous mammary tumors in mice: A meta-analysis
Energy restriction and the risk of spontaneous mammary tumors in mice: A meta-analysis
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DOI：
10.1002/ijc.11277
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发表时间：
2003-09-20
影响因子：
6.4
通讯作者：
van den Brandt, PA
中科院分区：
文献类型：
--
作者：
Dirx, MJM;Zeegers, MPA;van den Brandt, PA
我们的荟萃分析旨在对有关能量限制对小鼠自发性乳腺肿瘤影响的文献进行系统综述，并提供更精确的乳腺肿瘤风险汇总（汇总）估计。进行了敏感性分析，以了解动物研究之间的潜在异质性。使用以下术语进行文献检索，以识别相关文章：动物研究、乳腺肿瘤、限制脂肪、饮食碳水化合物、能量限制和热量限制。评估质量项目的标准清单（即，研究特征）的方法，旨在定量评估不同动物实验的异质性结果的潜在因素。发病率数据用于计算风险差异。通过随机效应Meta回归分析计算合并风险差异。本荟萃分析包括14项动物实验。无法识别发表偏倚。14项研究的合并风险差异为-0.55，95%置信区间较窄（-0.69; -0.41），这意味着能量限制动物组的乳腺肿瘤发生率比对照组低55%。基于研究特征，包括干预开始时小鼠的年龄、干预持续时间、小鼠分配、自由采食对照组的使用、小鼠生育力和提供能量的营养物质类型（脂肪、碳水化合物或蛋白质），在研究之间未检测到异质性。这项荟萃分析证实，能量限制本身一贯防止小鼠乳腺肿瘤的发展，无论限制营养素的类型或其他研究特征如何。(C)2003 Wiley-Liss，Inc.
Our meta-analysis was aimed at providing a systematic review of the literature regarding the effect of energy restriction on spontaneous mammary tumors in mice and at providing a more precise pooled (summary) estimate of the risk of mammary tumors. A sensitivity analysis was conducted to obtain insight in potential heterogeneity between the animal studies. A literature search was conducted with the following terms to identify relevant articles: animal studies, mammary tumors, fat restricted, dietary carbohydrates, energy restriction and calorie restriction. A criteria list for the assessment of quality items (i.e., study characteristics) in animal experiments was developed that was intended to quantitatively assess potential factors that underlie heterogeneous results of different animal experiments. Incidence figures were used to calculate the risk difference. The pooled risk difference was calculated by random effects meta regression analysis. Fourteen animal experiments were included in this meta-analysis. Publication bias could not be identified. The pooled risk difference for the 14 studies was -0.55 with a narrow 95% confidence interval (-0.69; -0.41), implying that the energy-restricted animal groups developed 55% less mammary tumors than the control groups. No heterogeneity could be detected between the studies based on study characteristics that included the age of mice at the start of intervention, duration of intervention, allocation of the mice, use of ad libitum control group, fertility of the mice and the type of energy-providing nutrient (fat, carbohydrate or protein). This meta-analysis confirms that energy restriction in itself consistently protects against the development of mammary tumor in mice, irrespective of the type of restricted nutrient or other study characteristics. (C) 2003 Wiley-Liss, Inc.