Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems.
Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems.
复制标题
将 siRNA 气溶胶输送至肺部。第 2 部分：基于纳米载体的递送系统。
DOI：
10.14356/kona.2017005
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Chougule MB
中科院分区：
文献类型：
--
作者：
Youngren-Ortiz SR;Gandhi NS;España-Serrano L;Chougule MB
本文综述和讨论了含有siRNA的工程纳米粒在吸入给药中的应用。通过使用精心设计的siRNA疗法，可以减轻已发现的蛋白质功能障碍的疾病。吸入给药途径为肺部治疗各种肺部疾病提供局部的siRNA治疗药物。SiRNA递送系统可用于克服肺部递送的障碍，如解剖屏障、粘液纤毛清除、咳嗽清除和肺泡巨噬细胞清除。除了裸露的siRNA气雾剂外，以前研究的siRNA载体系统包括脂类、聚合物、多肽或无机来源的载体系统。这些给药系统可以通过吸入器或雾化器产生气雾剂来实现肺部给药。本文将讨论这些siRNA纳米载体系统的制备方法。使用可吸入纳米载体siRNA递送系统对其有效递送存在障碍，但在制定安全有效的递送系统的同时克服这些限制将为吸入性药物领域提供独特的进步。
In this article, applications of engineered nanoparticles containing siRNA for inhalation delivery are reviewed and discussed. Diseases with identified protein malfunctions may be mitigated through the use of well-designed siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system can be used to overcome the barriers of pulmonary delivery, such as anatomical barriers, mucociliary clearance, cough clearance, and alveolar macrophage clearance. Apart from naked siRNA aerosol delivery, previously studied siRNA carrier systems include those of lipidic, polymeric, peptide, or inorganic origin. These delivery systems can achieve pulmonary delivery through the generation of an aerosol via an inhaler or nebulizer. The preparation methodologies for these siRNA nanocarrier systems will be discussed herein. The use of inhalable nanocarrier siRNA delivery systems have barriers to their effective delivery, but overcoming these constraints while formulating a safe and effective delivery system will offer unique advances to the field of inhaled medicine.