3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus
3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus
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DOI：
10.1016/j.fitote.2010.03.011
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发表时间：
2010-09-01
期刊：
影响因子：
3.4
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Arung, Enos Tangke;Shimizu, Kuniyoshi;Kondo, Ryuichiro
在我们努力从天然资源中寻找新的增白剂的过程中，我们将重点放在显示出抗黑素生成活性的木菠萝木材上。通过活性导向的A.从异苏木提取物中分离得到一个新的异戊烯基类黄酮化合物3-异戊烯基毛地黄黄酮（1）。1的蘑菇酪氨酸酶抑制活性的IC_（50）为76.3 μ M。与木犀草素的比较结果表明，异戊二烯基取代基在C-3。1位对揭示酪氨酸酶抑制起重要作用。在对B16黑色素瘤细胞的黑色素形成抑制中，1的IC 50为56.7 μ M，具有较小的细胞毒性。(C)2010 Elsevier B. V.保留所有权利。
In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 mu M. The results of the comparison with that of luteolin showed the prenyl substituent at C-3. position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC50 of 1 was 56.7 mu M with less cytotoxicity. (C) 2010 Elsevier B.V. All rights reserved.