Engineering two-dimensional silicene composite nanosheets for dual-sensitized and photonic hyperthermia-augmented cancer radiotherapy
Engineering two-dimensional silicene composite nanosheets for dual-sensitized and photonic hyperthermia-augmented cancer radiotherapy
复制标题
工程二维硅烯复合纳米片用于双敏化和光子热疗增强癌症放射治疗
DOI：
10.1016/j.biomaterials.2020.120455
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发表时间：
2021-02-03
期刊：
影响因子：
14
通讯作者：
Wu, Rong
中科院分区：
文献类型：
--
作者：
Hu, Ruizhi;Chen, Zhixin;Wu, Rong
纳米技术的快速发展引发了大量治疗癌症的纳米平台的出现。硅烯作为一种新兴的二维（2D）材料，由于其良好的生物降解和强大的光热转换性能，近年来被探索作为治疗剂。然而，如何合理设计硅基复合材料以进一步发挥其多功能的医疗应用仍是一个极具挑战性的课题。在此，我们报道了硅烯基silicene@Pt复合纳米片的构建，用于计算机断层扫描(CT)/光声（PA）成像引导双增敏放疗联合光子肿瘤热疗，这是通过种子生长方法在硅烯纳米片表面原位生长Pt组分来实现的。特别是，通过Pt组分的功能化，这些纳米片可以作为CT成像的造影剂和放射治疗的双重放射增敏剂，它可以沉积Pt相关的辐射能量（增敏治疗过程I），并克服肿瘤微环境中过表达的H2O2产生的Pt催化O-2产生的缺氧相关放射阻力（增敏治疗过程II）。硅烯纳米片强大的光热转换性能不仅使silicene@Pt复合纳米片具有光声成像特性，而且实现了光子肿瘤热疗，实现了与放疗的联合治疗效果。这项工作不仅拓宽了硅烯的生物医学应用，而且为硅烯的多功能生物医学应用开发了功能化策略。
The rapid development of nanotechnology has triggered the emerging of tremendous theranostic nanoplatforms for combating cancers. Silicene, as an emerging two-dimensional (2D) material, has been recently explored as therapeutic agent due to their desirable biodegradation and strong photothermal-conversion performance. However, the rational design of silicene-based composites for further exerting multifunctional medical applications is still highly challenging. Herein, we report on the construction of silicene-based silicene@Pt composite nanosheets for computed tomography (CT)/photoacoustic (PA) imaging-guided dual-sensitized radiotherapy combined with photonic tumor hyperthermia, which has been achieved by a seed-growth approach to in situ grow Pt components onto silicene nanosheets' surface. Especially, by functionalization of Pt components, these nanosheets could act as both contrast agents for CT imaging and dual radio-sensitizing agents for radiotherapy, which could deposit Pt-involved radiation energy (sensitized therapeutic process I) and overcome hypoxiaassociated radio-resistance by Pt-catalytic O-2 generation from overexpressed H2O2 within the tumor microenvironment (sensitized therapeutic process II). The strong photothermal-conversion performance of silicene nanosheets not only endowed silicene@Pt composite nanosheets with photoacoustic imaging property, but also realized the photonic tumor hyperthermia and achieved a combined therapeutic effect with radiotherapy. This work not only broadens the biomedical applications of silicene, but also develops functionalization strategies of silicene for versatile biomedical applications.