CINRG pilot trial of oxatomide in steroid-naive Duchenne muscular dystrophy
CINRG pilot trial of oxatomide in steroid-naive Duchenne muscular dystrophy
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DOI：
10.1016/j.ejpn.2007.02.009
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发表时间：
2007-11-01
影响因子：
3.1
通讯作者：
Escolar, Diana M.
中科院分区：
文献类型：
--
作者：
Buyse, Gunnar M.;Goemans, Nathalie;Escolar, Diana M.
作者报告了一项在14名5-10岁的未接受过类固醇治疗的DMD男孩中进行的开放标签双中心治疗性试验。3个月无药物导入期和6个月治疗期之间的线性演变比较显示，肌肉力量的定量（QMT）和手动（MMT）测量和定时功能测试无显著差异。不能排除随着时间的推移强度退化的适度缓解。(C)2007年欧洲儿科神经病学学会。由爱思唯尔有限公司出版。保留所有权利。
The authors report a pilot open-label two-center therapeutic trial of oxatomide in 14 steroid-naive DMD boys aged 5-10 years. Comparison of linear evolutions between 3 months medication-free lead-in periods and 6 months treatment periods showed no significant differences in quantitative (QMT) and manual (MMT) measurements of muscle strength and timed functional tests. A modest mitigation of strength deterioration over time cannot be excluded. (C) 2007 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.