The International HapMap Project Web site
The International HapMap Project Web site
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DOI：
10.1101/gr.4413105
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发表时间：
2005-11-01
期刊：
影响因子：
7
通讯作者：
Stein, LD
中科院分区：
文献类型：
--
作者：
Thorisson, GA;Smith, AV;Stein, LD
HapMap网站http://www.hapmap.org是国际单倍型图计划基因型数据的主要门户。在该项目的第一阶段，在来自全球四个人群的270个个体中对> 110万个SNP进行了基因分型。HapMap网站为研究人员提供了许多工具，使他们能够分析数据以及下载数据进行本地分析。本文介绍了使用这些工具的分步指南，包括检索基因型和频率数据的指南，挑选用于关联研究的标签SNP，以图形方式查看单倍型，并检查标记到标记LD模式。
The HapMap Web site at http://www.hapmap.org is the primary portal to genotype data produced as part of the International Haplotype Map Project. In phase I of the project, > 1.1 million SNPs were genotyped in 270 individuals from four worldwide populations. The HapMap Web site provides researchers with a number of tools that allow them to analyze the data as well as download data for local analyses. This paper presents step-by-step guides to using those tools, including guides for retrieving genotype and frequency data, picking tag-SNPs for use in association studies, viewing haplotypes graphically, and examining marker-to-marker LD patterns.