Comparison of fluorine-18 deoxyglucose and O-15 water PET in temporal lobe epilepsy.
Comparison of fluorine-18 deoxyglucose and O-15 water PET in temporal lobe epilepsy.
复制标题
氟-18脱氧葡萄糖和O-15水PET在颞叶癫痫中的比较。
作者：
R. Tatlidil;S. Luther;A. West;H. Jadvar;T. Kingman
本研究比较了氟-18脱氧葡萄糖正电子发射断层扫描(FDG-PET)和O-15水(H_2(15)O)PET对复杂部分性癫痫患者发作灶的定侧作用。对35例因难治性癫痫行前颞叶切除术的患者的分析表明，FDG-和H2(15)O-PET在显示癫痫灶方面具有很高的相关性。FDG-和H2(15)O-PET分别有83%和77%的病例显示明显的不对称性。MRI视觉分析的定侧化程度低于FDG和血流成像。发作期脑电(EEG)定侧与血流部位和FDG-PET异常一致。33例(94%)患者术后无癫痫发作或明显好转。总之，与FDG-PET相比，血流PET产生了相似的结果，在颞叶癫痫患者的术前评估中可以作为一种有价值的方式。
This study reports a comparison of Fluorine-18 deoxyglucose positron emission tomography (FDG-PET) and O-15 water (H2(15)O) PET with regard to lateralization of the seizure focus in patients with complex partial epilepsy. The analysis of 35 patients who had an anterior temporal lobectomy for medically intractable seizures indicated that FDG- and H2(15)O-PET were highly correlated in demonstrating the epileptic focus. FDG- and H2(15)O-PET showed significant asymmetries in 83% and 77% of cases respectively. The lateralization with visual analysis of MRI was found to be lower than both FDG and blood flow imaging. Ictal electroencephalography (EEG) lateralizations were concordant with sites of blood flow and FDG-PET abnormalities. Thirty-three patients (94%) were seizure-free or improved significantly after surgery. In conclusion, blood flow PET yielded similar results compared to FDG-PET and can be a valuable modality in preoperative evaluation of patients with temporal lobe epilepsy.